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Abstract
Background. Because blood flow modulates endothelial prostacyclin production, the extent of this
production in autologous vein grafts implanted in poor distal runoff limbs needed
to be examined.
Methods. Endothelial prostacyclin production in canine autologous vein grafts was measured
in poor distal runoff limbs (poor runoff group) and compared with findings in normal
runoff limbs (control group). Vein grafts were perfused in a closed circuit at 3 days
and 1, 2, 3, and 4 weeks after implantation; after perfusion for the first 30 minutes
in a steady flow (basal prostacyclin production), the grafts were exposed to arachidonic
acid (stimulated prostacyclin production) for the following 30 minutes. Prostacyclin,
as the metabolite 6-keto-PGF1α, was radioimmunoassayed.
Results. Basal and stimulated prostacyclin production increased in both groups during a period
of time after implantation. At 2 weeks when endothelialization was complete, prostacyclin
production in the poor runoff group was impaired, compared with the findings in the
control group, and this difference increased with time. At 4 weeks the stimulated
prostacyclin production was 18.91 ± 4.03 ng/cm2 in the control group and 11.60 ± 1.67 ng/cm2 in the poor runoff group (p < 0.05).
Conclusions. We propose that the impaired capacity of the vein graft to produce prostacyclin in
a poor distal runoff may lead to loss of graft patency in reconstructed arteries.
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Article info
Publication history
Accepted:
March 18,
1992
Footnotes
☆Supported by a grant-in-aid for general scientific research (no. 02670549) from the Ministry of Education, Science, and Culture of Japan.
Identification
Copyright
© 1993 Published by Elsevier Inc.
