Abstract
Background. This study was done to review the clinical presentation, surgical management, and
prognostic factors for primary gastrointestinal sarcomas. Methods. We reviewed medical records of 55 patients who were treated for primary gastrointestinal
sarcomas from 1981 through 1996. Mean follow-up time was 32 months. Results. Clinical findings included gastrointestinal bleeding (51%), palpable mass (36%),
and abdominal pain (33%). The stomach was the most common site of disease (53%), followed
by the small intestine (33%). Tumors were high grade in 76% of patients and low-grade
in 24% of patients. Complete resection of all gross disease was accomplished in 35
patients (64%), incomplete resection in 17 patients (31%), and biopsy only in 3 patients
(5%). Adjacent organ resection was required in 19 patients (35%). Overall actuarial
survival was 22% (median survival, 32 months). Unfavorable prognostic factors were
incomplete resection, high-grade histologic features, and tumor size of 5 cm or more
(P <.05). En bloc resection of contiguous organs did not adversely effect survival.
In patients with complete resections, tumor grade was the most important prognostic
factor (median survival, 55 months vs 19 months for low-grade vs high-grade tumors;
P <.05). Conclusions. Aggressive surgical resection, including en bloc resection of locally advanced tumors,
appears warranted. Despite complete resections, patients with high-grade tumors remain
at risk for recurrence. (Surgery 2000;128:604-12.)
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Article info
Footnotes
*Reprint requests: Mark S. Talamonti, MD, Northwestern University Medical School, Department of Surgery, 675 N St Clair, Galter 17-250, Chicago, IL 60611.
**Surgery 2000;128:604-12
Identification
Copyright
© 2000 Mosby, Inc. Published by Elsevier Inc. All rights reserved.
