Advertisement
Central Surgical Association| Volume 128, ISSUE 4, P702-707, October 2000

Bilateral synchronous breast cancer: Mode of detection and comparison of histologic features between the 2 breasts

      Abstract

      Background. Bilateral synchronous breast cancer is uncommon (accounting for 1.0%-2.6% of all patients with breast cancer), and most physicians do not accumulate a large personal experience of patients with this disease. We reviewed our experience with patients with bilateral synchronous breast cancer, focusing on the mode of detection and histologic features in the 2 breasts. Methods. The charts of patients who were treated at this institution for bilateral synchronous breast cancer during the 15-year period of 1984 through 1999 were reviewed. Information regarding age, mode of detection, histopathologic features, treatment, and overall survival were analyzed. Results. During the study period, 51 patients (all women) were treated at our institution for bilateral synchronous breast cancer. This comprised 2.1% of all patients (n = 2382 patients) treated for breast cancer during the same period of time. The first cancer was detected by palpation in 81% and by mammography in 14%. The corresponding figures for the contralateral cancer were 24% and 54%, respectively. The histologic type of cancer was identical in the 2 breasts in 29 patients (57%) and was different between the 2 breasts in 22 patients (43%). The overall 10-year survival rate was 63%. Conclusions. Bilateral synchronous breast cancer is often detected by mammography and is frequently of the same histologic type as the index cancer. A better awareness of the risk for this disease may help detect bilateral breast cancer earlier. (Surgery 2000;128:702-7.)
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Surgery
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Chaudary MA
        • Millis RR
        • Hoskins EO
        • et al.
        Bilateral primary breast cancer: a prospective study of disease incidence.
        Br J Surg. 1984; 71: 711-714
        • Sterns EE
        • Fletcher WA.
        Bilateral cancer of the breast: a review of clinical, histologic, and immunohistologic characteristics.
        Surgery. 1991; 110: 617-622
        • Bernstein JL
        • Thompson WD
        • Risch N
        • Holford TR.
        Risk factors predicting the incidence of second primary breast cancer among women diagnosed with a first primary breast cancer.
        Am J Epidemiol. 1992; 136: 925-936
        • Gogas J
        • Markopoulos C
        • Skandalakis P
        • Gogas H.
        Bilateral breast cancer.
        Am Surg. 1993; 59: 733-735
        • Graham MD
        • Yelland A
        • Peacock J
        • Beck N
        • Ford H
        • Gazet JC.
        Bilateral carcinoma of the breast.
        Eur J Surg Oncol. 1993; 19: 259-264
        • Singletary SE
        • Taylor SH
        • Guinee VF
        • Whitworth Jr., PW
        Occurrence and prognosis of contralateral carcinoma of the breast.
        J Am Coll Surg. 1994; 178: 390-396
        • Gollamudi SV
        • Gelman RS
        • Peiro G
        • et al.
        Breast conservation therapy for stage I-II synchronous bilateral breast carcinoma.
        Cancer. 1997; 79: 1362-1369
        • Yeatman TJ
        • Lyman GH
        • Smith SK
        • Reintgen DS
        • Cantor AB
        • Cox CE.
        Bilaterality and recurrence for lobular breast cancer: considerations for treatment.
        Ann Surg Oncol. 1997; 4: 198-202
        • Robinson E
        • Rennert G
        • Rennert HS
        • Neugut AI.
        Survival in bilateral breast cancer.
        Cancer. 1993; 71: 172-176
        • de Ustarán JK
        • Meiss RP
        Primary synchronous bilateral breast cancer: epidemiological approach.
        Breast Cancer Res Treat. 1988; 12: 311-314
        • Dawson LA
        • Chow E
        • Goss PE.
        Evolving perspectives in contralateral breast cancer.
        Eur J Cancer. 1998; 34: 2000-2009
        • Fracchia AA
        • Robinson D
        • Legaspi A
        • Greenall MJ
        • Kinne DW
        • Groshen S.
        Survival in bilateral breast cancer.
        Cancer. 1985; 55: 1414-1421
        • Al-Jurf AS
        • Jochimsen PR
        • Urdanetta IF
        • Scott D.
        Factors influencing survival in bilateral breast cancer.
        J Surg Oncol. 1981; 16: 3433-3448
        • King RE
        • Terz JJ
        • Lawrence W.
        Experience with opposite breast biopsy in patients with operable breast cancer.
        Cancer. 1976; 37: 43-45
        • Staren ED
        • Robinson DA
        • Witt TR
        • Economou SG.
        Synchronous, bilateral mastectomy.
        J Surg Oncol. 1995; 59: 75-79
        • Morrow M
        • Jordan VC
        • Takei H
        • Gradishar WJ
        • Pierce LJ.
        Current controversies in breast cancer management.
        Curr Probl Surg. 1999; 36: 163-216
        • Heaton KM
        • Peoples GE
        • Singletary SE
        • et al.
        Feasibility of breast conservation therapy in metachronous or synchronous breast cancer.
        Ann Surg Oncol. 1999; 6: 102-108
        • Fischer ER
        • Fischer B
        • Sass R
        • et al.
        Pathologic findings from the National Surgical Adjuvant Breast Project.
        Cancer. 1984; 54 (Protocol No. 4): 3002-3011
      1. SEER cancer statistics review, 1973-1997. National Cancer Institute, Bethesda (MD)2000