Transcription factors regulate gene expression by cooperating with the RNA polymerase
II enzyme to synthesize messenger RNA molecules (mRNA) that are then used to produce
proteins. Because they control the protein repertoire expressed by a cell, transcription
factors critically regulate all physiologic processes. Not surprisingly, alterations
in transcription factors have significant impact on diseases and their treatment.
This article reviews basic concepts about the functions and regulation of transcription
factors that are important for better understanding cell physiology, pathophysiology,
and molecular medicine. A particular focus of our discussion will be the implications
of this knowledge in the fields of surgery and transplantation. Better understanding
of the functions of transcription factors will facilitate the design of novel therapies
for some human diseases, and the control of biologic responses after surgery and transplantation.
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Article info
Publication history
Accepted:
February 8,
2000
Footnotes
*Supported by the Mayo Foundation and the National Institutes of Health grants GM59763 to K. H. and DK52912 to R. U.
**Reprint requests: Dr Raul Urrutia, Gastroenterology Research Unit, 2-445A Alfred Building, 200 First St SW, Mayo Clinic, Rochester, MN 55905.
★Surgery 2000;128:1-5.)
Identification
Copyright
© 2000 Mosby, Inc. Published by Elsevier Inc. All rights reserved.
