Abstract
Background. The aggressiveness of familial non-medullary thyroid cancer (FNMTC) has been a subject
of debate. The purpose of the study was to determine whether FNMTC is more aggressive
than sporadic thyroid cancer. Methods. A multicenter retrospective matched-case control study of FNMTC versus sporadic non-medullary
thyroid cancer was conducted. Disease-free survival (time to recurrence) for both
groups was compared. Results. Forty-eight familial cases were compared with 144 age-, gender-, and stage-matched
controls. Patients with FNMTC had a significantly shorter disease-free survival compared
with sporadic non medullary thyroid cancer. Patients with FNMTC who presented with
evidence of distant metastasis, or who were from families with more than 2 thyroid
cancer-affected members, had the worst prognosis. The available staging systems were
less likely to predict the outcome in patients with FNMTC than in patients with sporadic
non-medullary thyroid cancer unless one accounted for the strength of family history
in the staging system. Conclusions. FNMTC is more aggressive than sporadic non-medullary thyroid cancer. The best predictors
of a poor outcome in patients with FNMTC are the number of family members affected
by thyroid cancer and evidence of distant metastasis. (Surgery 2000;128:1043-51.)
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Article info
Footnotes
*Reprint requests: Osamah Alsanea, MD, Department of Surgery UCSF/Mount Zion Medical Center, 1600 Divisadero St, Rm C347, San Francisco, CA 94143-1674.
**Surgery 2000;128:1043-51.
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Copyright
© 2000 Mosby, Inc. Published by Elsevier Inc. All rights reserved.
