An unusual complication of warfarin therapy is warfarin-associated skin necrosis,
1
a condition we describe in a patient with factor V Leiden mutation. We speculate
that genetic variants of the thrombotic pathway may contribute to the development
of this disorder.To read this article in full you will need to make a payment
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References
- Late-onset warfarin-induced skin necrosis: case report and review of the literature.Am J Hematol. 1998; 52: 233-237
- Factor V Leiden mutation and the risks for thromboembolic disease: a clinical perspective.Ann Intern Med. 1997; 127: 895-903
- Warfarin induced skin necrosis associated with activated protein C resistance.Thromb and Haemost. 1996; 75 ([letter]): 523-524
- Warfarin-induced skin necrosis in a patient with a mutation of the prothrombin gene.N Engl J Med. 1999; 340 ([letter]): 735
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© 2000 Mosby, Inc. Published by Elsevier Inc. All rights reserved.
