Abstract
Background. Currently, there is only limited information regarding tumor angiogenesis and its
clinical implications in cases of esophageal carcinoma. The purpose of this study
was to clarify which clinicopathologic parameters correlate with tumor angiogenesis;
furthermore, the study was conducted to evaluate whether tumor angiogenesis is an
independent prognostic factor in cases of esophageal carcinoma. Methods. Intratumoral microvessel density (MVD) and thymidine phosphorylase (dThdPase) expression
were immunohistochemically studied after extended radical esophagectomy in 103 cases
of esophageal carcinoma. Results. Increased MVD significantly correlated with the depth of tumor invasion, the frequency
of intramural metastasis, and the stage of tumor advancement (P <.05). dThdPase expression status significantly correlated with the size and depth
of primary tumors (P <.02). A significant correlation was present between MVD and the expression status
of dThdPase (P <.01). Furthermore, increased MVD correlated with increased tumor recurrence after
esophagectomy and with poorer survival curves (P <.01 and P <.05, respectively). A multivariate analysis revealed MVD to be an independent predictor
of unfavorable prognosis. Conclusions. Tumor angiogenesis expressed as MVD correlates with clinicopathologic parameters
regarding tumor progression and is an independent prognostic indicator in patients
undergoing extended radical esophagectomy for invasive esophageal carcinoma. (Surgery
2001;129:302-8.)
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Article info
Publication history
Accepted:
August 20,
2000
Footnotes
☆Reprint requests: Satoru Nakagawa, MD, The First Department of Surgery, Niigata University School of Medicine, Asahimachi-dori 1-757, Niigata 951-8122, Japan.
☆☆Surgery 2001;129:302-8.
Identification
Copyright
© 2001 Mosby, Inc. Published by Elsevier Inc. All rights reserved.
