Letter| Volume 129, ISSUE 3, P384, March 2001

Mutations of the CYP2C9 gene and the response to warfarin

      In the August issue of the journal, Freeman et al (Surgery 2000;128:281-5) described an apparent association of cytochrome P450 (CYP) polymorphisms with reduced dosage requirements for the anticoagulant warfarin. Pooled data from patients being either heterozygous for the inactive CYP2A6*2 allele (2 subjects) or patients having mutations in the CYP2C9 gene (11 subjects) were compared with 25 patients with wild-type (normal) alleles.
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