Abstract
Background. Desmoid tumors associated with familial adenomatous polyposis (FAP) are locally invasive.
Often occurring in the mesentery of the intestine, they sometimes recur after resection.
Complications can include intestinal failure and dependence on parenteral nutrition.
We describe 9 patients who underwent intestinal transplantation for the treatment
of desmoid tumors associated with FAP. Methods. Records of patients undergoing intestinal transplantation for desmoid tumors at 2
transplant centers were reviewed for patient age, sex, type of graft, procedure date,
tumor site, desmoid complications, medications, extracolonic manifestations, status
at follow-up, and length of survival. Results. Nine patients with FAP and intestinal failure caused by desmoid tumors were treated
with isolated intestinal (n = 6), multivisceral (n = 2), or combined liver-intestinal
transplantation (n = 1). Desmoid tumors recurred in the abdominal walls of 2 patients.
Two patients died: one as a result of sepsis, the other because of a rupture of a
mycotic aneurysm of the aortic anastomosis. One graft lost to severe rejection was
replaced with a second intestinal graft. Eleven to 53 months after transplantation,
7 patients were alive, well, independent of parenteral treatment, and leading apparently
normal lifestyles. Conclusions. Transplantation of the intestine alone or as part of a multivisceral transplantation
may help rescue otherwise untreatable patients with complicated desmoid tumors. (Surgery
2001;129:277-81.)
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Article info
Publication history
Accepted:
August 6,
2000
Footnotes
☆Reprint requests: Andreas G. Tzakis, MD, Department of Surgery, Division of Liver and GI Transplant, University of Miami School of Medicine, Highland Professional Bldg, 6th Floor, 180 NW 9th St, Miami, FL 33136.
☆☆Surgery 2001;129:277-81.
Identification
Copyright
© 2001 Mosby, Inc. Published by Elsevier Inc. All rights reserved.
