Abstract
Background. The role of extrinsic autonomic nerves in regulation of colonic contractile activity
is not well understood. Methods. Twelve dogs had 6 strain gauge force transducers implanted in the colon and were
divided into 3 experimental groups: (1) a control group, (2) an extrinsic denervation
group (denervation group), and (3) an extrinsic denervation with proximal intrinsic
myenteric plexus transection group (denervation + transection group). After recovery,
colonic contractile activity during fasting and effects of feeding on gastrocolonic
response were recorded. Results. Colonic contractile activity occurred not only in the denervation group but also
in the denervation + transection group. Both mean duration and propagation time of
the colonic contractile activity were shorter in the denervation + transection group
than in the control group. In the denervation group, propagation time was shorter
than in the controls but the other parameters were not different. Feeding failed to
immediately induce the gastrocolonic response in both experimental groups. Conclusions. We conclude that extrinsic nerves are not required for the appearance of colonic
contractile activity. However, colonic contractile activity and its propagation are
modulated by extrinsic innervation or proximal intrinsic neural continuity. Gastrocolonic
response may be predominantly under extrinsic neural control. (Surgery 2002;132:471-9.)
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Article info
Publication history
Accepted:
May 3,
2002
Footnotes
*Reprint requests: Yoshitaka Tanabe, MD, Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
Identification
Copyright
© 2002 Mosby, Inc. Published by Elsevier Inc. All rights reserved.
