Abstract
Background. From a post hoc analysis a hypothesis was generated that women deposit more collagen
in a surrogate test wound than men. The purpose of this study has been to verify this
hypothesis prospectively in a controlled study. Methods. Post hoc analyses were done on 37 volunteers (study A). The prospective trial included
47 smoking volunteers (study B). Outcome measures were deposition levels of collagen
(hydroxyproline) and protein during a period of 10 days in subcutaneously implanted
tubes of expanded polytetrafluoroethylene. Results. The mean increments of collagen deposition levels in women as compared with men were
56% (P <.01) in study A and 74% (P <.001) in study B. The mean increase in the ratio collagen/total protein was 74%
(P <.001) and 69% (P <.001), indicating that the increase was specific for collagen. Conclusions. The studies show that deposition in a miniature subcutaneous test wound of collagen,
but not noncollagenous protein, is promoted in women as compared to men. These findings
may relate to the observation in some reports indicating higher rates of compromised
postoperative wound healing in men. (Surgery 2002;131:338-43.)
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Article info
Publication history
Accepted:
August 24,
2001
Footnotes
*Supported in part by Coloplast A/S, Denmark and The Foundation of A. & J. Louis Hansen, Denmark.
**Reprint requests: Professor Finn Gottrup, MD, DMedSci, Copenhagen Wound Healing Center, Dept S15, Bispebjerg University Hospital, DK-2400 Copenhagen NV, Denmark.
Identification
Copyright
© 2002 Mosby, Inc. Published by Elsevier Inc. All rights reserved.
