Abstract
Background. Most lacerations and surgical incisions are closed with sutures or staples. Octylcyanoacrylate
tissue adhesive (OCA) was recently approved for use in the United States. We compared
the cosmetic appearance of lacerations and incisions repaired with OCA versus standard
wound closure methods (SWC). Methods. A multicenter randomized clinical trial including patients with simple lacerations
or surgical incisions was conducted at 10 clinical sites. Patients were randomly assigned
to treatment with OCA or SWC. Follow-up was performed at 1 week and at 3 months to
determine infection rates and cosmetic outcome. Results. Eight hundred fourteen patients with 924 wounds (383 traumatic lacerations, 235 excisions
of skin lesions or scar revisions, 208 minimally invasive surgeries, and 98 general
surgical procedures) were enrolled. Groups were similar in baseline characteristics.
Wound closure with OCA was faster than with SWC (2.9 vs 5.2 minutes, P <.001). At 1 week infection rates were similar (OCA, 2.1% vs SWC, 0.7%; P =.09) and fewer OCA wounds were erythematous (18% vs 36%, P <.001). There were no differences in wound dehiscence rates (OCA, 1.6% vs SWC, 0.9%;
P =.35). At 3 months there was no difference in the percent of wounds with optimal
appearance (OCA, 82% vs SWC, 83%; P =.67). Conclusions. Repair of traumatic lacerations and surgical incisions with OCA is faster than with
SWC, and cosmetic outcome is similar at 3 months. (Surgery 2002;131:270-6.)
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Article info
Publication history
Accepted:
November 1,
2001
Footnotes
*Supported by a research grant from Closure Medical Corporation, Raleigh, NC, which developed TraumaSeal. Two of the authors (AJS, JEH) are on the speaker's bureau of Ethicon Inc.
**Reprint requests: Adam J. Singer, MD, Department of Emergency Medicine, Stony Brook University Hospital, L4-515, Stony Brook, NY 11794-7400.
★*Additional members of the study group are Dean M. Turiumi, MD, Daniel J. Piacquandio, MD, Dan Schlager, MD, Arthur Gilbert, MD, Marvin Hammond, MD, Steven Gordon, MD, Thomas Bruns, MD, James P. Stannard, MD, and Van Wahlgren, MD.
Identification
Copyright
© 2002 Mosby, Inc. Published by Elsevier Inc. All rights reserved.
