Billingham et al
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References
- “Actively acquired tolerance” of foreign cells.Nature. 1953; 172: 603-606
- Kidney transplantation with rabbit antithymocyte globulin induction and sirolimus monotherapy.Lancet. 2002; 360: 1662-1664
- Tolerogenic immunosuppression for organ transplantation.Lancet. 2003; 361: 1502-1510
- Proper tolerance, perioperative campath 1H, and low-dose cyclosporine monotherapy in renal allograft recipients.Lancet. 1998; 351: 1701-1702
- Mixed chimerism and transplantation tolerance.Annu Rev Med. 2001; 52: 353-370
- Outcomes of recipients of both bone marrow and solid organ transplants: a review.Medicine. 1998; 77: 355-369
- Reconstitution with syngeneic plus allogeneic or xenogeneic bone marrow leads to specific acceptance of allografts or xenografts.Nature. 1984; 307: 168-170
- Mixed chimerism and permanent specific transplantation tolerance induced by a non-lethal preparative regimen.J Exp Med. 1989; 169: 493-502
- Durable mixed allogeneic chimerism and tolerance by a nonlethal radiation-based cytoreductive approach.J Immunol. 1996; 157: 2820-2829
- Specific tolerance induction and transplantation: a single-day protocol.Blood. 1997; 89: 2596-2601
- Long-lasting skin allograft tolerance in adult mice induced across fully allogeneic (multimajor H-2 plus multiminor histocompatibility) antigen barriers by a tolerance-inducing method using cyclophosphamide.J Exp Med. 1989; 169: 213-238
- Long-term engraftment of normal and post-5-fluorouracil murine marrow into normal nonmyeloablated mice.Blood. 1993; 81: 2566-2571
- Induction of high levels of allogeneic hematopoietic reconstitution and donor-specific tolerance without myelosuppressive conditioning.Nature Med. 1997; 3: 783-787
- Minimal conditioning required in a murine model of T cell depletion, thymic irradiation and high-dose bone marrow transplantation for the induction of mixed chimerism and tolerance.Transplant Int. 2002; 15: 248-253
- Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways.Nature. 1996; 381: 434-438
- Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates.Nature Med. 1999; 5: 686-693
- The role of T cell costimulatory activation pathways in transplant rejection.N Engl J Med. 1998; 338: 1813-1821
- Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance.Nature Med. 1999; 5: 1298-1302
- Long-term survival of skin allografts induced by donor splenocytes and anti-CD154 antibody in thymectomized mice requires CD4+ T cells, interferon-γ, and CTLA4.J Clin Invest. 1998; 101: 2446-2455
- Genetic characterization of strain differences in the ability to mediate CD40/CD28-independent rejection of skin allografts.J Immunol. 2000; 165: 6849-6857
- Prevention of renal allograft rejection in primates by blocking the B7/CD28 pathway.Transplantation. 1999; 68: 1010-1018
- Anti-CD40 therapy extends renal allograft survival in rhesus macaques.Transplantation. 2002; 74: 933-940
- Extrathymic T cell deletion and allogeneic stem cell engraftment induced with costimulatory blockade is followed by central T cell tolerance.J Exp Med. 1998; 187: 2037-2044
- Costimulation blockade, busulfan, and bone marrow promote titratable macrochimerism, induce transplantation tolerance, and correct genetic hemoglobinopathies with minimal myelosuppression.J Immunol. 2001; 167: 1103-1111
- Allogeneic chimerism with low-dose irradiation, antigen presensitization, and costimulator blockade in H-2 mismatched mice.Blood. 2001; 97: 557-564
- Allogeneic hematopoietic chimerism in mice treated with sublethal myeloablation and anti-CD154 antibody: absence of graft-versus-host disease, induction of skin allograft tolerance, and prevention of recurrent autoimmunity in islet-allografted NOD/Lt mice.Blood. 2000; 95: 2175-2182
- Requirements for the promotion of allogeneic engraftment by anti-CD154 (anti-CD40L) monoclonal antibody under nonmyeloablative conditions.Blood. 2001; 98: 467-474
- Mechanisms involved in the establishment of tolerance through costimulatory blockade and BMT: Lack of requirement for CD40L-mediated signaling for tolerance or deletion of donor-reactive CD4+ cells.Am J Transplant. 2001; 1: 339-349
- The influence of immunosuppressive drugs on tolerance induction through bone marrow transplantation with costimulation blockade.Blood. 2003; 101: 2886-2893
- Allogeneic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment.Nature Med. 2000; 6: 464-469
- Administration of anti-CD40 ligand and donor bone marrow leads to hematopoietic chimerism and donor-specific tolerance without cytoreductive conditioning.J Immunol. 2000; 165: 1-4
- Primed allospecific T cells prevent the effects of costimulatory blockade on prolonged cardiac allograft survival in mice.Am J Transplant. 2002; 2: 501-509
- In vivo T cell depletion in miniature swine using the swine CD3 immunotoxin, pCD3-CRM9.Transplantation. 1999; 68: 855-860
- Stable mixed chimerism and tolerance using a nonmyeloablative preparative regimen in a large-animal model.J Clin Invest. 2000; 105: 173-181
- Cytokine-mobilized peripheral blood progenitor cells for allogeneic reconstitution of miniature swine.Transplantation. 2000; 69: 135-140
- Mixed chimerism without whole body irradiation in a large animal model.J Clin Invest. 2000; 105: 1779-1789
- Variable relationship between chimerism and tolerance after hematopoietic cell transplantation without myelosuppressive conditioning.Transplantation. 2002; 74: 1535-1544
- Stable mixed hematopoietic chimerism in DLA-identical littermate dogs given sublethal total body irradiation before and pharmacological immunosuppression after marrow transplantation.Blood. 1997; 89: 3048-3054
- Stable mixed chimerism in dogs given donor antigen, CTLA4Ig, and 100 cGy total body irradiation before and pharmacologic immunosuppression after marrow transplant.Blood. 1999; 94: 2523-2529
- Cytotoxic T lymphocyte antigen 4-immunoglobulin fusion protein combined with methotrexate/cyclosporine as graft-versus-host disease prevention in a canine dog leukocyte antigen-nonidentical marrow transplant model.Transplantation. 2000; 69: 450-454
- Mixed allogeneic chimerism and renal allograft tolerance in cynomolgus monkeys.Transplantation. 1995; 59: 256-262
- Modifications of the conditioning regimen for achieving mixed chimerism and donor-specific tolerance in cynomolgus monkeys.Transplantation. 1997; 64: 709-716
- Costimulatory blockade for induction of mixed chimerism and renal allograft tolerance in nonhuman primates.Transplant Proc. 2001; 33: 221-222
- Induction of kidney allograft tolerance after transient lymphohematopoietic chimerism in patients with multiple myeloma and end-stage renal disease.Transplantation. 2002; 74: 1405-1409
- Mixed chimerism and immunosuppressive drug withdrawal after HLA- mismatched kidney and hematopoietic progenitor transplantation.Transplantation. 2002; 73: 1386-1391
Article info
Publication history
Accepted:
October 25,
2003
Footnotes
☆Supported in part by grants from the Roche Organ Transplantation Research Foundation (#110578928) and National Institutes of Health RO1 grants HL49915 and AI05558.
Identification
Copyright
© 2004 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
