Background
Invasive pancreatic carcinoma originating from the body and tail usually is diagnosed
at a late stage, and resection is considered a palliative procedure because of the
poor prognosis. Factors predicting survival were not evaluated fully in patients with
invasive pancreatic carcinoma of the body and tail who had undergone distal pancreatectomy
with extended lymphadenectomy.
Methods
Between 1990 and 2004, 88 patients with invasive pancreatic carcinoma of the body
and tail underwent distal pancreatectomy with extended lymphadenectomy. Univariate
and multivariate models were used to analyze the effects of clinicopathologic factors
on long-term survival.
Results
No operative deaths occurred. The median survival time was 22 months, and the 1-,
3-, and 5-year survival rates were 76%, 40%, and 19%, respectively. Lymph node involvement
status and the degree of histologic vein invasion were independent predictors of long-term
survival.
Conclusions
Distal pancreatectomy with extended lymphadenectomy for the treatment of invasive
pancreatic carcinoma of the body and tail contributed to long-term survival in selected
patients without mortality. Effective postoperative treatment should be evaluated
in patients with positive lymph nodes and/or the presence of histologic vein invasion
even after a curative resection because long-term survival cannot be expected.
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Article info
Publication history
Accepted:
August 5,
2002
Footnotes
Supported by a Grant-in-Aid for cancer research from the Ministry of Health, Labour and Welfare of Japan.
Identification
Copyright
© 2006 Mosby, Inc. Published by Elsevier Inc. All rights reserved.
