Hypothesis
If (1) 3-hydroxy-3-methylglutaryl-coenzyme reductase inhibitors (statins) block the
rate-limiting step in cholesterol synthesis and promote the expression of low-density
lipoprotein receptors, (2) “Gram-negative sepsis” results from an abundant systemic
response to bacterial lipopolysaccharide (endotoxin), (3) triglyceride-rich lipoproteins
can bind endotoxin and low-density lipoprotein receptors enhance the uptake of both
of these molecules, and (4) low-density lipoprotein receptor internalization of lipoproteins
and endotoxin co-opts a common transcriptional regulatory system (NF-κB) that results
in reduced cell vulnerability to inflammation, then statins, in addition to their lipid-lowering capacity, enhance endotoxin clearance
from the circulation and attenuate the septic response.
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Article info
Publication history
Accepted:
August 23,
2005
San Francisco, CalifIdentification
Copyright
© 2006 Mosby, Inc. Published by Elsevier Inc. All rights reserved.
