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Background. Lymph node metastasis is a risk factor for the occurrence of peritoneal dissemination
and liver metastasis in patients with gastric cancer.
Methods. We analyzed data on 324 patients with serosally invasive gastric cancer, with respect
to the relation between lymphatic invasion and potential for tumor growth and metastasis.
All these patients were curatively treated in the Department of Surgery II, Kyushu
University.
Results. Lymphatic invasion was evident in 214 patients, in whom vascular invasion was more
frequent and the rate of lymph node metastasis was higher compared with patients with
no lymphatic invasion. There was no difference in tumor size. The type of recurrence
varied and the prognosis was poor in patients with lymphatic invasion. The DNA ploidy
pattern was higher, and the levels of proliferating cell nuclear antigen labeling
and argyrophilic nucleolar organizer regions count were significantly higher in tumor
tissues with lymphatic invasion than in those without invasion.
Conclusions. Gastric cancers with characteristics of lymphatic invasion have higher proliferating
activities, and metastases to distant organs are likely.
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Article info
Publication history
Accepted:
July 25,
1994
Footnotes
†Supported by grant-in-aid for scientific research (C) (06671286) from the Ministry of Education, Science and Culture in Japan.
Identification
Copyright
© 1995 Mosby-Year Book, Inc. Published by Elsevier Inc.
