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Background. The purpose of this study was to determine how transection and reanastomosis of the
intestinal wall influences postprandial motor activity and transit in the small intestine.
Methods. Six dogs were each instrumented with 12 strain gauge transducers, two collection
cannulas, and an infusion catheter defining a 100 cm study segment in the midjejunum.
The animals underwent baseline measurements of postprandial motor activity and transit
rate after 650 kcal solid and liquid meals. Postprandial motor activity was analyzed
by computer methods that identify frequency, duration, amplitude, and propagation
behavior of smooth muscle contractions. After the baseline measurements were performed,
each animal underwent transection and reanastomosis of the intestinal wall at sites
marked during the initial laparotomy. Measurements of postprandial motor activity
and transit were repeated and compared with control values.
Results. Transection decreased frequency, amplitude, and percent propagation for postprandial
contractions. Total propagating area per minute significantly decreased from 382±20
gram-seconds/minute to 190±66 gram-seconds/minute after transection (p<0.05). Intestinal
transit decreased from 13.5±1.5 cm/min to 8.5±2.4 cm/min (p<0.05). The change in transit
was related primarily to a change in frequency of propagating contractions (r=0.767;
p=0.004).
Conclusions. Transection and reanastomosis of the intestinal wall changes the temporal and spatial
organization of contractions distal to the transection site. The net result is fewer
distally propagating contractions and slower intestinal transit.
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Article info
Publication history
Accepted:
September 21,
1994
Footnotes
1Supported in part by the Department of Veterans Affairs Medical Research Service.
Identification
Copyright
© 1995 Mosby-Year Book, Inc. Published by Elsevier Inc.
