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Background. The effects of transmurally relased heparin on the patency of microvenous anastomoses
were studied by using a bioerodible polymer delivery system in a rat microvascular
thrombosis model.
Methods. A polyanhydride carrier with heparin was wrapped around the outside of a highly thrombogenic
venous inversion graft in 14 animals, and patency rates were compared with those of
17 control animals.
Results. Anastomotic patency was significantly greater in the groups treated with transmurrally
released heparin, measured both at 24 hours (86% versus 16%; p<0.02) and at 7 days
(86% versus 36%; p<0.05) after operation. No significant complications occurred.
Conclusions. Controlled release of heparin by transmural delivery is an effective and safe form
of local antithrombotic therapy and may have applications both in microvascular and
large vessel surgery.
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Article info
Footnotes
*Supported by National Institutes of Health grant T-32-DC00018, BSF#910021.
*Presented in a preliminary report at the Research Forum of the American Academy of Otolaryngology-Head and Neck Surgery, Sept. 9–13, 1990, in San Diego, Calif.
Identification
Copyright
© 1995 Mosby-Year Book, Inc. Published by Elsevier Inc.
