Minimizing the false negative rate of sentinel lymph node biopsy (SLNB) is a worthy goal, as decisions on systemic treatment
for breast cancer may depend on axillary nodal status. Substantial research efforts
have helped to improve SLNB techniques and to maximize the technical success of lymphatic
mapping and reduce the false negative rate.
1
In less than 10 years, mapping techniques have improved from early technical success
rates of 80-85% to 97% plus.
2
Due to improved technical success and a lower false negative rate with a combination
technique,
2
,
3
,
4
lymphatic mapping with both dye and isotope is the preferred technique endorsed recently
in a consensus statement of the American Society of Breast Surgeons.
5
However, the consensus statement does not specify injection site for tracers.To read this article in full you will need to make a payment
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References
- Technical advances in sentinel lymph node biopsy for breast cancer.Am Surg. 2004; 70: 407-413
- A trend analysis of the relative value of blue dye and isotope localization in 2,000 consecutive cases of sentinel node biopsy for breast cancer.J Am Coll Surg. 2001; 193: 473-478
- Practical guidelines for optimal gamma probe detection of sentinel lymph nodes in breast cancer.Surgery. 2000; 128: 139-144
- Dermal injection of radioactive colloid is superior to peritumoral injection for breast cancer sentinel lymph node biopsy.Ann Surg. 2001; 233: 676-687
- Consensus statement on guidelines for performing sentinel lymph node dissection in breast cancer. 2005 (Fourth revision, December. Available from: http://www.breastsurgeons.org. Accessed March 6, 2006.)
- Double mapping with subareolar blue dye and peritumoral green dye injections decreases the false-negative rate of dye-only sentinel node biopsy for early breast cancer.Surgery. 2006; 139: 624-629
- Sentinel lymph node biopsy for breast cancer.J Am Coll Surg. 2001; 192: 684-691
- The hottest sentinel lymph node is not always the positive node.Am Surg. 2004; 70: 475-478
- Biology of lymphatic metastases in breast cancer.Ann Surg Oncol. 2002; 9: 467-471
- Highest isotope count does not predict sentinel node positivity in all breast cancer patients.Ann Surg Oncol. 2001; 8: 592-597
- Concordance and validation study of sentinel lymph node biopsy for breast cancer using subareolar injection of blue dye and technetium 99m sulfur colloid.J Am Coll Surg. 2002; : 467-475
- Subareolar and peritumoral injection identify similar sentinel nodes for breast cancer.Ann Surg Oncol. 2002; 9: 169-176
Article info
Publication history
Accepted:
December 23,
2005
Identification
Copyright
© 2006 Mosby, Inc. Published by Elsevier Inc. All rights reserved.
