Evidence-based surgical hypothesis| Volume 141, ISSUE 1, P7-8, January 2007

Download started.


Blood doping in the surgical intensive care unit: Evidence-based surgical rebuttal

      A hypothesis by Wan et al
      • Wan J.J.
      • Mortensen E.
      • Knudson M.M.
      • Harken A.H.
      Blood doping in the surgical intensive care unit.
      suggests that critically ill patients in the surgical intensive care unit might benefit from being transfused to a normal hematocrit. They attempt to justify their opinion by citing references to the beneficial effects of blood doping in the sports medicine literature. Wouldn’t it be wonderful if patients behaved like world class athletes? However, they do not.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Surgery
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Wan J.J.
        • Mortensen E.
        • Knudson M.M.
        • Harken A.H.
        Blood doping in the surgical intensive care unit.
        Surgery. 2006; 140: 6-8
        • Rao S.V.
        • Jollis J.G.
        • Harrington R.A.
        • Granger C.B.
        • Newby L.K.
        • Armstrong P.W.
        • et al.
        Relationship of blood transfusion and clinical outcomes in patients with acute coronary syndromes.
        JAMA. 2004; 292: 1555-1562
        • Palmieri T.L.
        • Caruso D.M.
        • Foster K.N.
        • Cairns B.A.
        • Peck M.D.
        • Gamelli R.L.
        • et al.
        Effect of blood transfusion on outcome after major burn injury: a multicenter study.
        Crit Care Med. 2006; 34: 1602-1607
        • Shah D.M.
        • Gottlieb M.E.
        • Rahm R.L.
        • Stratton H.H.
        • Barie P.S.
        • Paloski W.H.
        • et al.
        Failure of red blood cell transfusion to increase oxygen transport or mixed venous PO2 in injured patients.
        J Trauma. 1982; 22: 741-746
        • Dietrich K.A.
        • Conrad S.A.
        • Hebert C.A.
        • Levy G.L.
        • Romero M.D.
        Cardiovascular and metabolic response to red blood cell transfusion in critically ill volume-resuscitated nonsurgical patients.
        Crit Care Med. 1990; 18: 940-944
        • Kahn R.C.
        • Zaroulis C.
        • Goetz W.
        • Howland W.S.
        Hemodynamic oxygen transport and 2,3-diphosphoglycerate changes after transfusion of patients in acute respiratory failure.
        Intensive Care Med. 1986; 12: 22-25
        • Casutt M.
        • Seifert B.D.
        • Pasch T.
        • Schmid E.R.
        • Turina M.I.
        • Spahn D.R.
        Factors influencing the individual effects of blood transfusions on oxygen delivery and oxygen consumption.
        Crit Care Med. 1999; 27: 2194-2200
        • Marik P.E.
        • Sibbald W.J.
        Effect of stored-blood transfusion on oxygen delivery in patients with sepsis.
        JAMA. 1993; 269: 3024-3029
        • Lorente J.A.
        • Landin L.
        • De Pablo R.
        • Renes E.
        • Rodriguez-Diaz R.
        • Liste D.
        Effects of blood transfusion on oxygen transport variables in severe sepsis.
        Crit Care Med. 1993; 21: 1312-1318
        • Gramm J.
        • Smith S.
        • Gamelli R.L.
        • Dries D.J.
        Effect of transfusion on oxygen transport in critically ill patients.
        Shock. 1996; 5: 190-193
        • Bourgoin A.
        • Leone M.
        • Delmas A.
        • Garnier F.
        • Albanese J.
        • Martin C.
        Increasing mean arterial pressure in patients with septic shock: effects on oxygen variables and renal function.
        Crit Care Med. 2005; 33: 780-786
        • Jellama W.T.
        • Groeneveld A.B.J.
        • Wesseling K.H.
        • Thijs L.G.
        • Westerhof N.
        • van Lieshout J.J.
        Heterogeneity and prediction of hemodynamic responses to dobutamine inpatients with septic shock.
        Crit Care Med. 2006; 34: 2392-2398
        • Lindstedt Sl
        • Conley K.E.
        Human aerobic performance: too much ado about limits to Vo2.
        J Exp Biol. 2001; 204: 3195-3199
        • Spriet L.L.
        • Gledhill N.
        • Froese A.B.
        • Wilkes D.L.
        Effect of graded erthrocythemia on cardiovascular and metabolic responses to exercise.
        J Appl Physiol. 1986; 61: 1942-1948
        • Taylor R.W.
        • O’Brien J.
        • Trottier S.J.
        • Manganaro
        • Cytron M.
        • Lesko M.F.
        • et al.
        Red blood cell transfusions and nosocomial infections in critically ill patients.
        Crit Care Med. 2006; 34: 2302-2308
        • Barone J.E.
        • Lowenfels A.B.
        Maximization of oxygen delivery: a plea for moderation.
        J Trauma. 1992; 33: 651-653