Background
In severe acute pancreatitis, multiple organ dysfunction syndrome and infectious complications
are contributors to high mortality. Interleukin (IL)-15 is a novel cytokine that shares
many biologic properties with IL-2. Serum IL-15 levels have not yet been determined
in SAP.
Methods
Serum IL-15 concentrations were measured in 54 patients with severe acute pancreatitis
on admission. The relationships with severity, organ dysfunction, infection, and prognosis
were analyzed. Utility of IL-15 for the prediction of clinical outcome was evaluated
by receiver operator characteristic (ROC) curve analysis.
Results
Serum IL-15 levels were increased significantly in severe acute pancreatitis (5.8
± 0.5 pg/mL), and they were correlated with Ranson, APACHE II, and Japanese severity
score. Serum IL-15 levels were greater in patients with organ dysfunction, patients
with infection, and nonsurvivors (P < 05 each). Incidences of organ dysfunction in patients whose IL-15 levels were less
than 3.0, 3.0-5.3, and greater than or equal to 5.3 pg/mL, were 8%, 31%, and 89%,
respectively (P < .001). Usefulness of IL-15 for the prediction of organ dysfunction was superior
to CRP, IL-6, and IL-8, and it was similar to Ranson, APACHE II, and Japanese severity
score. Incidences of infection in patients whose IL-15 levels were less than 5.5,
5.5-9.0, and greater than or equal to 9.0 pg/mL, were 7%, 25%, and 50%, respectively
(P < .05). Mortality rates in patients whose IL-15 levels were less than 5.5, 5.5-9.0,
and greater than or equal to 9.0 pg/mL, were 11%, 25%, and 80%, respectively (P < .001). Usefulness of IL-15 for the prediction of death was superior to CRP, IL-6,
and IL-8.
Conclusions
Serum IL-15 level is a useful predictor of the complications (especially organ dysfunction)
and mortality in severe acute pancreatitis.
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Article info
Publication history
Accepted:
May 5,
2007
Footnotes
Supported by Grant-in-Aid for Scientific Research from the Ministry of Education, Science, Sports and Culture of Japan, and Grant-in-Aid for Scientific Research from the Ministry of Health, Labor and Welfare of Japan.
Identification
Copyright
© 2007 Mosby, Inc. Published by Elsevier Inc. All rights reserved.
