Gastric cancer (GC) remains a leading cause of cancer-related deaths worldwide,
1
even though a decrease in its incidence and mortality rate has been observed in recent
decades.
2
Although the incidence of intestinal GC has declined gradually, the incidence of
diffuse gastric cancer (DGC) has remained stable. Most GCs are sporadic and seem to
result from the cumulative effects of different environmental risk factors; smoking,
alcohol consumption, and dietary habits have been addressed as important risk factors.
3
,
4
,
5
Helicobacter pylori (H pylori) infection and gene polymorphisms of proinflammatory cytokines represent
other features of this process that leads to the development of GC.
6
,
7
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Article info
Publication history
Accepted:
June 1,
2007
Footnotes
Supported by Grant PAR 2004 to the University of Siena and by Grant MIUR 2005 to the Unit of Surgical Oncology, University of Siena, Italy.
Identification
Copyright
© 2007 Mosby, Inc. Published by Elsevier Inc. All rights reserved.
