Background
Gastric electrical stimulation (GES) is known to improve vomiting with short pulses,
normalize dysrhythmia with long pulses, and accelerate gastric emptying with 2 channels.
The aim of this study was to assess the effects of a new method GES, namely, 2-channel
GES with dual pulses on gastric emptying of solids as well as gastric dysrhythmia
and emetic responses.
Methods
Seven beagle dogs implanted with 4 pairs of electrodes were studied. A novel method
of GES was proposed: 2-channel dual-pulse GES in which each stimulus was composed
of a short pulse followed with a long pulse, and stimulation was delivered at 2 different
locations. The study was performed to test the effects of this new method of GES on
vasopressin-induced delayed gastric emptying of solids, gastric dysrhythmia, and emetic
responses.
Results
(1) Vasopressin-induced gastric dysrhythmia and emetic responses, as well as delayed
gastric emptying of solids (P < .01). (2) Two-channel, but not 1-channel, dual-pulse GES was able to accelerate
vasopressin-induced delayed gastric emptying of solids. (3) Both 1- and 2-channel
dual-pulse GES was capable of improving dysrhythmia and emetic responses (P < .01).
Conclusions
The novel method of 2-channel dual-pulse GES is capable of accelerating gastric emptying
of solids and improving dysrhythmia and emetic responses induced by vasopressin. This
new method of GES may have a potential for gastroparesis.
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Article info
Publication history
Published online: November 30, 2007
Accepted:
July 1,
2007
Footnotes
Partially support by grants from NIH (DK066709 and DK063733).
Identification
Copyright
© 2008 Mosby, Inc. Published by Elsevier Inc. All rights reserved.
