Letter to the Editor| Volume 143, ISSUE 1, P153, January 2008

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Reply: Evaluation of cross-linked poly gamma-glutamic acid and interceed in a rat adhesion model

      We thank Dr. Rajab and collegues for a careful, and critical reading of our study. The following are our responses.
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        • Izumi Y.
        • Yamamoto M.
        • Kawamura M.
        • Adachi T.
        • Kobayashi K.
        Cross-linked poly (gamma-glutamic acid) attenuates peritoneal adhesion in a rat model.
        Surgery. 2007; 141: 678-681
        • Wiseman D.M.
        • Gottlick-Iarkowski L.
        • Kamp L.
        Effect of different barriers of oxidized regenerated cellulose (ORC) on cecal and sidewall adhesions in the presence and absence of bleeding.
        J Invest Surg. 1999; 12: 141-146

      Linked Article

      • Evaluation of cross-linked poly gamma-glutamic acid and Interceed in a rat adhesion model
        SurgeryVol. 143Issue 1
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          Izumi and colleagues show that poly gamma-glutamic acid (PGA) but not Interceed attenuates adhesion formation in their model involving cecum abrasion and sharp excision of the parietal peritoneum with underlying musculature.1 We would like to point out that Interceed is ineffective in the presence of blood.2 Unfortunately the authors do not state whether their protocol with drying and subsequent exposure to room air resulted in complete hemostasis at the time of adhesion prophylaxis. Moreover, the authors do not reveal the proportion of animals with material residues at the time of relaparotomy.
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