This study was designed to assess the early host tissue incorporation of several polypropylene lightweight (PP-LW) meshes used to repair abdominal wall defects and to correlate collagen deposition with the biomechanical response shown by PP-LW versus polypropylene heavyweight (PP-HW) meshes.
Ventral hernial defects (7 × 5 cm) were created in the anterior abdominal wall of New Zealand rabbits and repaired by fixing PP-LW mesh of different pore sizes or a low porosity HW mesh to the edges of the defect. Rabbits were killed 14 days after implant, and specimens were taken from the central mesh area to examine collagen deposition by light microscopy, real time reverse transcription polymerase chain reaction, immunohistochemistry, and Western blotting. The biomechanical resistance of the biomaterials was also assessed.
All the materials showed excellent incorporation in host tissue. Relative amounts of collagen III mRNA were considerably higher than collagen I mRNA. Higher collagen I and III mRNA levels were noted for pore sizes equal to or greater than 3.45 ± 0.19 mm2 (Ultrapro®/Optilene Elastic®). These two meshes showed significantly higher levels of collagen III than Parietene® and Surgipro® with smaller pores. Biomechanical resistance values for Optilene® were significantly higher than those recorded for Surgipro® and Parietene®.
(a) LW meshes of pore size larger than 3 mm2 induced the genetic overexpression of collagen types I and III; (b) the larger pore-sized LW meshes induced more collagen type III deposition and its faster conversion to collagen I; (c) Optilene®, the most porous LW mesh examined, showed the greatest tensile strength 14 days after implant.
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Surgery
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- Mesh compared with non-mesh methods of open groin hernia repair: Systematic Review of randomized controlled trials.Br J Surg. 2000; 87: 854-859
- Hernias: inguinal and incisional.Lancet. 2003; 362: 1561-1571
- Incisional abdominal hernia: the open mesh repair.Langenbecks Arch Surg. 2004; 389: 1-5
- The argument for lightweight polypropylene mesh in hernia repair.Surg Innov. 2005; 12: 63-69
- Integrations of biomaterials implanted into abdominal wall: process of scar formation and macrophage response.Biomaterials. 1995; 16: 381-387
- Functional and morphologic properties of a modified mesh for inguinal hernia repair.World J Surg. 2002; 26: 1472-1480
- Functional and morphological evaluation of a low-weight monofilament polypropylene mesh for hernia repair.J Biomed Mater Res. 2002; 63: 129-136
- Textile analysis of heavy weight, mid-weight, and light weight polypropylene mesh in a porcine ventral hernia model.J Surg Res. 2006; 136: 1-7
- Heavy-weight versus low-weight polypropylene meshes for open sublay mesh repair of incisional hernia.Eur J Med Res. 2005; 10: 247-253
- Functional impairment and complaints following incisional hernia repair with different polypropylene meshes.Hernia. 2001; 5: 142-147
- Are meshes with lightweight construction strong enough?.Int Surg. 2005; 90: S10-S12
- Randomized clinical trial assessing impact of a lightweight or heavyweight on chronic pain after inguinal hernia repair.Br J Surg. 2005; 92: 166-170
- Randomized clinical trial comparing lightweight composite mesh with polyester or polypropylene mesh for incisional hernia repair.Br J Surg. 2005; 92: 1488-1493
- Experimental comparison of monofile light and heavy polypropylene meshes: less weight does not mean less biological response.World J Surg. 2006; 30: 1586-1591
- Partially absorbable meshes for hernia repair offer advantages over nonabsorbable meshes.Am J Surg. 2007; 194: 68-74
- Cleavage of structural proteins during the assembly of the head of bacteriophage T4.Nature. 1970; 227: 660-685
- Electrophoretic transfer of proteins from polyacrylamide gels into nitrocellulose sheets: procedure and applications.Proc Natl Acad Sci U S A. 1979; 76: 4350-4354
- The lightweight and large porous mesh concept for hernia repair.Expert Rev Med Devices. 2005; 2: 103-117
- Experimental comparison of monofile light and heavy polypropylene meshes: less weight does not mean less biological response.World J Surg. 2007; 31: 867-868
- Impact of polymer pore size on the interface scar formation in a rat model.J Surg Res. 2002; 103: 208-214
- The influence of differing pore sizes on the biocompatibility of two polypropylene meshes in the repair of abdominal defect: experimental study in dogs.Hernia. 2001; 5: 59-64
- Tissue response to polypropylene meshes used in the repair of abdominal wall defects.Biomaterials. 1998; 19: 669-675
Published online: July 18, 2008
Accepted: April 9, 2008
© 2008 Mosby, Inc. Published by Elsevier Inc. All rights reserved.