Hypothesis
Impaired wound healing in diabetics is due to pathologic angiogenesis, which is a
result of aberrant sphingosine-1-phosphate signaling. Pharmacologic modulation of
sphingosine-1-phosphate-dependent signaling normalizes healing in diabetic wounds.
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Article info
Publication history
Published online: August 25, 2009
Accepted:
April 6,
2009
Footnotes
Supported by National Institute of Diabetic and Digestive and Kidney Diseases Grant 9T32DK078514-06A2 (K.N.G.) and National Institutes of Health Grants CA77528 and GM66954 (J.D.S.).
Identification
Copyright
© 2010 Mosby, Inc. Published by Elsevier Inc. All rights reserved.
