Background
Previously, utilizing a disease-specific outcome tool (Parathyroidectomy Assessment
Of Symptoms or PAS scores) for hyperparathyroidism (HPT), parathyroidectomy was shown
to decrease many of the vague nonspecific symptoms associated with HPT. The purpose
of this study was to assess whether this improvement persists in the long term.
Methods
PAS Scores and quality of life (QOL) measures were mailed to patients previously enrolled
in the primary HPT study, including the thyroidectomy comparison group. Data were
compared pre-operatively, 1 and 10 years after operation.
Results
Of the original 122 HPT patients, 78 (64%) and 39/58 (68%) of the thyroidectomy patients
participated. The pre-operative PAS score in the HPT group was 318; this decreased
to 177 at 1 year and 189 at 10 years (P < .05). In contrast, thyroidectomy had PAS scores of 170 pre-operatively, 190 at
1 year, and 174 at 10 years (P = .1). HPT patients were more symptomatic pre-operatively compared to the thyroidectomy
group (318 vs 170; P < .05), yet at 1 and 10 years, there were no differences. QOL was better in the HPT
group at 10 years compared to pre-operatively (P < .05).
Conclusion
This prospective study demonstrates the long-term benefit of parathyroidectomy in
primary HPT patients. Decrease of their pre-operative symptoms appears to have contributed
to their improved QOL at 10 years.
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Article info
Publication history
Accepted:
October 5,
2009
Footnotes
Presented at AAES 2009.
Support for this study was provided through the Endocrine Surgical Research Foundation in the Department of Surgery, University of Calgary.
Identification
Copyright
© 2009 Published by Elsevier Inc. All rights reserved.
