Letter to the Editor| Volume 147, ISSUE 4, P595-596, April 2010

Download started.


Pathophysiology and treatment of the systemic inflammatory response syndrome from the perspective of evolutionary medicine

Published:January 11, 2010DOI:
      To the Editors:
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Surgery
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Lyte M.
        Reciprocal gut-brain evolutionary symbiosis provokes and amplifies the postinjury systemic inflammatory response syndrome.
        Surgery. 2009; 146: 950-954
        • Fujita T.
        • Yanaga K.
        Clinical influence of vagotomy on postoperative acute phase response.
        Langenbeck Arch Surg. 2007; 392: 127-130
        • van Westerloo D.J.
        • Giebelen I.A.
        • Florquin S.
        • Daalhuisen J.
        • Bruno M.J.
        • de Vos A.F.
        • et al.
        The cholinergic anti-inflammatory pathway regulates the host response during septic peritonitis.
        J Infect Dis. 2005; 191: 2138-2148
        • Guarini S.
        • Altavilla D.
        • Cainozzo M.M.
        • Giuliani D.
        • Bigiani A.
        • Mairini H.
        • et al.
        Efferent vagal fibre stimulation blunts nuclear factor-kappaB activation and protects against hypovolemic hemorrhagic shock.
        Circulation. 2003; 107: 1189-1194
        • Rangel-Frausto M.S.
        • Pittet D.
        • Costigan M.
        • Hwang T.
        • Davis C.S.
        • Wenzel R.P.
        The natural history of the systemic inflammatory response syndrome (SIRS). A prospective study.
        JAMA. 1995; 273: 117-123
        • Girbes A.R.J.
        • Beishuizen A.
        Strack van Schijndd RJM. Pharmacological treatment of sepsis.
        Fundam Clin Pharmacol. 2008; 22: 355-361
        • Gammelgaard A.
        Evolutionary biology and the concept of disease.
        Med Health Care Philos. 2000; 3: 109-116