Background
Sigmoid diverticulitis (SD) is common in the West; its incidence is increasing as
the average age of the population increases. The aim of this study was to assess the
clinical outcomes of patients with acute SD and to determine whether emergency operation
was associated more often with previous episodes of acute diverticulitis.
Methods
All consecutive patients admitted for acute SD were recruited prospectively over an
11-year period from January 1998 to December 2008. Multiple logistic regression was
used to identify risk factors for free perforation.
Results
We included 934 patients (490 men and 444 women; median age, 59.2 years): 450 (48.2%)
presented for their first SD episode and 484 (51.8%) had a prior history of SD. Free
perforation occurred in 152 patients: during the first episode of SD in 114 patients
(25.3%), during the second in 29 (12.7%), during the third in 8 (5.9%), and during
the fifth in 1 patient (0.9%; P < .001). No patient with >5 previous episodes of SD had free perforation. All 152
patients with free perforation required emergent operative intervention. After initial
conservative therapy in 782 patients, 82 required early elective operative intervention
owing to exacerbation of infection under antibiotic treatment. Late elective colectomy
was performed in 299 patients during the inflammation-free interval, and operative
intervention was recommended in 345 patients owing to complicated diverticulitis.
Uncomplicated SD in 56 patients was managed conservatively. Comorbidity (>1 disorder)
and the first episode of SD were identified as risk factors for free perforation on
multiple logistic regression.
Conclusion
The risk of free perforation in acute SD decreases with the number of previous episodes
of SD. The first episode thus is the most dangerous for a free perforation. The indication
for colectomy should not be made based on the potential risk of free perforation.
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Article info
Publication history
Published online: December 13, 2010
Accepted:
October 18,
2010
Identification
Copyright
© 2011 Mosby, Inc. Published by Elsevier Inc. All rights reserved.
