Background
The objective of this study was to examine the clinicopathologic characteristics of
solid pseudopapillary tumors (SPTs) of the pancreas, including the risk factors for
disease recurrence and their effects on survival.
Methods
The medical records of 114 patients who underwent surgery for a pathologically confirmed
SPT between January 1995 and December 2007 were reviewed retrospectively.
Results
Of the 114 patients, 98 (86.9%) were female, and the median age was 36 years (range,
11–75). All 114 patients underwent curative intent surgery and 13 (11.4%) underwent
laparoscopic surgery. Of the 114 patients, 26 (22.8%) had solid pseudopapillary carcinoma
(SPC). There were no differences in any clinical factors between the benign SPT and
SPC groups; however, the only 4 recurrences identified were in the SPC group. After
follow-up ranging from 11 to 177 months, all 114 patients were alive, with only 4
showing evidence of recurrence. Recurrence was observed in young patients with metastasis
at first operation, invasion of an adjacent organ, and a large mass (≥13 cm).
Conclusion
Adequate operative resection including laparoscopic surgery is the mainstay of treatment
for SPT. Although statistically significant risk factors for recurrence cannot be
determined, tumor metastasis at the first operation, invasion of adjacent organ, large
tumor size, young patient age, tumor rupture, and inadequate resection may increase
the risk of recurrence. Our results demonstrate that long-term survival could be achieved
by aggressive operative resection and interventional treatment of recurrent disease.
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to SurgeryAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Tumors of the pancreas.in: Atlas of tumor pathology. Armed Forces Institute of Pathology, Washington, DC1959: 32-33
- The malignant nature of papillary and cystic neoplasm of the pancreas.Cancer. 1991; 68: 153-158
- Solid and papillary epithelial neoplasm of the pancreas.J Surg Oncol. 2004; 85: 193-198
- Solid pseudopapillary tumors of the pancreas: review of 718 patients reported in English literature.J Am Coll Surg. 2005; 200: 965-972
- Current diagnosis and management of unusual pancreatic tumors.Am J Surg. 2008; 196: 100-113
- Solid-pseudopapillary tumor of the pancreas: a typically cystic carcinoma of low malignant potential.Semin Diagn Pathol. 2000; 17: 66-80
- Histological typing of tumours of the exocrine pancreas: World Health Organization international histological classification of tumours.2nd ed. Springer-Verlag, New York1996
- Solid-papillary tumors of the pancreas: histopathology.JOP. 2006; 7: 131-136
- Postoperative pancreatic fistula: an international study group (ISGPF) definition.Surgery. 2005; 138: 8-13
- Rates of complications and death after pancreaticoduodenectomy: risk factors and the impact of hospital volume.Ann Surg. 2000; 232: 786-795
- Solid-pseudopapillary neoplasm.in: Hamilton S.R. Aaltonene L.A. World Health Organization classification of tumors: pathology and genetics of tumors of the digestive system. IARC Press, Lyon (France)2000: 246-248
- TNM residual tumor classification revisited.Cancer. 2002; 94: 2511-2516
- Loss of E-cadherin and cytoplasmic-nuclear expression of beta-catenin are the most useful immunoprofiles in the diagnosis of solid-pseudopapillary neoplasm of the pancreas.Hum Pathol. 2008; 39: 251-258
- Solid-pseudopapillary tumor of the pancreas: a surgical enigma?.Ann Surg Oncol. 2002; 9: 35-40
- Pancreatic solid-cystic papillary tumor: clinical features, imaging findings and operative management.JOP. 2006; 7: 137-144
- Solid-pseudopapillary tumors of the pancreas are genetically distinct from pancreatic ductal adenocarcinomas and almost always harbor beta-catenin mutations.Am J Pathol. 2002; 160: 1361-1369
- Frequent beta-catenin mutation and cytoplasmic/nuclear accumulation in pancreatic solid-pseudopapillary neoplasm.Cancer Res. 2001; 61: 8401-8404
- Clinical experiences of solid pseudopapillary tumors of the pancreas in China.J Gastroenterol Hepatol. 2008; 23: 1847-1851
- Solid pseudopapillary neoplasms of the pancreas: an updated experience.J Surg Oncol. 2007; 95: 640-644
- Solid pseudopapillary tumor of the pancreas suggesting malignant potential.Pancreas. 2006; 32: 276-280
- Surgical management of solid-pseudopapillary neoplasms of the pancreas (Franz or Hamoudi tumors): a large single-institutional series.J Am Coll Surg. 2009; 208 (discussion 7-9): 950-957
- Pancreatic solid-cystic-papillary tumor: clinicopathologic features in eight patients from Hong Kong and review of the literature.World J Surg. 1999; 23: 1045-1050
- Solid papillary neoplasm of the pancreas: a case report.Tumori. 2006; 92: 459-461
- Solid and papillary epithelial neoplasm of the pancreas: imaging-pathologic correlation on 56 cases.Radiology. 1996; 199: 707-711
- Solid pseudopapillary neoplasm of the pancreas: distinct patterns of onset, diagnosis, and prognosis for male versus female patients.Surgery. 2008; 143: 29-34
- Endoscopic ultrasound-guided fine-needle aspiration for diagnosis of solid pseudopapillary tumors of the pancreas: a multicenter experience.Endoscopy. 2008; 40: 200-203
- Do not biopsy solid psdudopapillary tumors of the pancreas!.Endoscopy. 2008; 40: 959
- Clinically aggressive solid pseudopapillary tumors of the pancreas: a report of two cases with components of undifferentiated carcinoma and a comparative clinicopathologic analysis of 34 conventional cases.Am J Surg Pathol. 2005; 29: 512-519
- Solid pseudopapillary tumour of the pancreas: diverse presentation, outcome and histology.JOP. 2006; 7: 635-642
- Solid-pseudopapillary tumours of the pancreas: 14 years experience.ANZ J Surg. 2005; 75: 684-689
- Expression of Wnt target genes in solid pseudopapillary tumor of the pancreas: a pilot study.Pancreas. 2009; 38: e53-e59
- Liver transplantation for multiple liver metastases from solid pseudopapillary tumor of the pancreas.J Pediatr Surg. 2007; 42: e27-e31
- Diffuse peritoneal carcinosis of pseudo-papillary and solid tumor of the pancreas. Role of abdominal injury.Gastroenterol Clin Biol. 1997; 21 ([in French]): 789-793
- Solid-pseudopapillary carcinoma of the pancreas.Pathol Int. 1999; 49: 231-234
- Solid-pseudopapillary tumor of the pancreas (Frantz tumor) in children: report of four cases and review of the literature.J Surg Oncol. 2001; 76: 289-296
- Treatment of liver metastases from a solid pseudopapillary tumor of the pancreas.J Hepatobiliary Pancreat Surg. 2006; 13: 587-590
- Solid-pseudopapillary tumor of the pancreas: clinical experience and literature review.World J Gastroenterol. 2005; 11: 1403-1409
- Solid pseudopapillary tumor of the pancreas with metastases to the lung and liver.Pathol Int. 2005; 55: 792-796
- Solid pseudopapillary tumor of the pancreas: a multicenter study of 23 pediatric cases.J Pediatr Surg. 2006; 41: 1992-1995
- Solid and pseudopapillary tumor of the pancreas—review and new insights into pathogenesis.Am J Surg Pathol. 2006; 30: 1243-1249
- Malignant potential of solid pseudopapillary neoplasm of the pancreas.Br J Surg. 2006; 93: 733-737
- Liver metastasis four years after Whipple's resection for solid-pseudopapillary tumor of the pancreas.JOP. 2007; 8: 223-227
- Aggressive behaviour of solid-pseudopapillary tumor of the pancreas in adults: a case report and review of the literature.World J Gastroenterol. 2008; 14: 960-965
Article info
Publication history
Published online: February 07, 2011
Accepted:
November 9,
2010
Identification
Copyright
© 2011 Mosby, Inc. Published by Elsevier Inc. All rights reserved.
