Background
In colorectal surgeries, surgical site infections (SSIs) frequently cause morbidity;
an incidence of up to 20% has been shown in previous studies. Recently, to prevent
microbial colonization of suture material in operative wounds, triclosan-coated polyglactin
suture materials with antimicrobial activity have been developed; however, their significance
in colorectal surgery remains unclear. This randomized controlled trial was conducted
to assess the value of triclosan-coated polyglactin sutures in colorectal surgery.
Methods
A total of 410 consecutive patients who had undergone elective colorectal operations
were enrolled in this trial. Of those patients, the 206 in the study group underwent
wound closure with triclosan-coated polyglactin 910 antimicrobial sutures, and the
204 patients in the control group received conventional wound closures with polyglactin
910 sutures.
Results
The study group and the control group were comparable regarding risk factors for SSIs.
The incidence of wound infection in the study group was 9 of 206 patients (4.3%),
and that in the control group was 19 of 204 patients (9.3%). The difference is statistically
significant in the 2 groups (P = .047). The median additional cost of wound infection management was $2,310. The
actual entire additional cost, therefore, of 9 patients in the study group was $18,370,
and that of 19 patients in the control group was $60,814.
Conclusion
Triclosan-coated sutures can reduce the incidence of wound infections and the costs
in colorectal surgery.
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Article info
Publication history
Published online: December 26, 2012
Accepted:
November 16,
2012
Identification
Copyright
© 2013 Mosby, Inc. Published by Elsevier Inc. All rights reserved.
