Background
Glypican-3 (GPC3), an oncofetal protein, is overexpressed in hepatocellular carcinoma
(HCC). The diagnostic efficacy of GPC3 for HCC has been evaluated intensively in recent
years; however, the prognostic value of GPC3 for HCC has not been well clarified.
The purpose of this study was to investigate the relationship between GPC3 and postoperative
patient survival in a prospective database.
Methods
GPC3 protein was detected by immunohistochemistry. The relationship between GPC3 expression
level and patients' clinicopathologic factors was analyzed. Kaplan-Meier survival
analysis was used to calculate patients' survival and was compared by using the log
rank test. The Cox regression model was used to identify the risk factors associated
with prognosis.
Results
GPC3 was expressed in 84% of HCC tissues. GPC3 protein expression was correlated with
the number of tumors (P = .015), serum alpha-fetoprotein (AFP) level (P = .011), and TNM stage (P = .006). High GPC3 expression was an independent risk factor for poor postoperative
disease-free survival (hazard ratio [HR] = 0.469; 95% confidence interval [CI] 0.303–0.727;
P = .001); and overall survival (HR = 0.435; 95% CI, 0.257–0.736; P = .002). Stratification analysis indicated that GPC3 had a good predictive value
for tumor recurrence in patients with HCC who have normal serum AFP levels. Also,
GPC3 expression status could predict the outcomes of patients with stage I disease.
Conclusion
GPC3 is a potential and reliable biomarker for predicting tumor recurrence and overall
survival in HCC patients after curative resection.
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Article info
Publication history
Published online: April 18, 2013
Accepted:
February 5,
2013
Footnotes
Supported by grants from Natural Science of Guangdong Province (No. S2011010002572) and the Science and Technology Project of Guangdong Province (No. 2009B030801124).
Identification
Copyright
© 2013 Mosby, Inc. Published by Elsevier Inc. All rights reserved.
