Evidence-Based Surgical Hypothesis| Volume 154, ISSUE 3, P632-637, September 2013

Acidic lactate sequentially induced lymphogenesis, phlebogenesis, and arteriogenesis (ALPHA) hypothesis: Lactate-triggered glycolytic vasculogenesis that occurs in normoxia or hypoxia and complements the traditional concept of hypoxia-based vasculogenesis

      Our hypothesis, ALPHA (Acidic Lactate sequentially induced Lymphogenesis, PHlebogenesis, and Arteriogenesis) proposes that lactate triggers vasculogenesis to manage lactate levels and complements the traditional vasculogenesis hypothesis. The teleologic basis for glycolytic vasculogenesis is primariy to produce drainage vessels, initially lymphatics but subsequently veins.
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