Background and aims
Mucin 5AC (MUC5AC) is a glycoprotein found in different epithelial cancers, including
biliary tract cancer (BTC). The aims of this study were to investigate the role of
MUC5AC as serum marker for BTC and its prognostic value after operation with curative
intent.
Patients and method
From January 2007 to July 2012, a quantitative assessment of serum MUC5AC was performed
with enzyme-linked immunoassay in a total of 88 subjects. Clinical and biochemical
data (including CEA and Ca 19-9) of 49 patients with BTC were compared with a control
population that included 23 patients with benign biliary disease (BBD) and 16 healthy
control subjects (HCS).
Results
Serum MUC5AC was greater in BTC patients (mean 17.93 ± 10.39 ng/mL) compared with
BBD (mean 5.95 ± 5.39 ng/mL; P < .01) and HCS (mean 2.74 ± 1.35 ng/mL) (P < .01). Multivariate analysis showed that MUC5AC was related with the presence of
BTC compared with Ca 19-9 and CEA: P < .01, P = .080, and P = .463, respectively. In the BTC group, serum MUC5AC ≥14 ng/mL was associated with
lymph-node metastasis (P = .050) and American Joint Committee on Cancer and International Union for Cancer
Control stage IVb disease (P = .047). Moreover, in patients who underwent operation with curative intent, serum
MUC5AC ≥14 ng/mL was related to a worse prognosis compared with patients with lesser
levels, with 3-year survival rates of 21.5% and 59.3%, respectively (P = .039).
Conclusion
MUC5AC could be proposed as new serum marker for BTC. Moreover, the quantitative assessment
of serum MUC5AC could be related to tumor stage and long-term survival in patients
with BTC undergoing operation with curative intent.
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Article info
Publication history
Published online: December 16, 2013
Accepted:
December 6,
2013
Identification
Copyright
© 2014 Mosby, Inc. Published by Elsevier Inc. All rights reserved.
