Case Report| Volume 155, ISSUE 4, P729-730, April 2014

Early development of a celiac trunk aneurysm during anti-vascular endothelial growth factor receptor therapy

Published:December 30, 2013DOI:
      Treatment with angiogenesis inhibitors frequently shows promising results in a wide spectrum of metastatic cancers (reviewed in Meadows et al
      • Meadows K.L.
      • Hurwitz H.I.
      Anti-VEGF therapies in the clinic.
      ). Hence, attention to specific side effects is of great interest.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Surgery
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Meadows K.L.
        • Hurwitz H.I.
        Anti-VEGF therapies in the clinic.
        Cold Spring Harb Perspect Med. 2012; 2
        • Huang Y.K.
        • Hsieh H.C.
        • Tsai F.C.
        • Chang S.H.
        • Lu M.S.
        • Ko P.J.
        Visceral artery aneurysm: risk factor analysis and therapeutic opinion.
        Eur J Vasc Endovasc Surg. 2007; 33: 293-301
        • Verheul H.M.
        • Pinedo H.M.
        Possible molecular mechanisms involved in the toxicity of angiogenesis inhibition.
        Nat Rev Cancer. 2007; 7: 475-485
        • Schutz F.A.
        • Je Y.
        • Richards C.J.
        • Choueiri T.K.
        Meta-analysis of randomized controlled trials for the incidence and risk of treatment-related mortality in patients with cancer treated with vascular endothelial growth factor tyrosine kinase inhibitors.
        J Clin Oncol. 2012; 30: 871-877
        • Ferrari G.
        • Pintucci G.
        • Seghezzi G.
        • Hyman K.
        • Galloway A.C.
        • Mignatti P.
        VEGF, a prosurvival factor, acts in concert with TGF-beta1 to induce endothelial cell apoptosis.
        Proc Natl Acad Sci U S A. 2006; 103: 17260-17265