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Gender bias in biomedical research

Published:September 25, 2014DOI:https://doi.org/10.1016/j.surg.2014.07.005
      Women have been achieving near parity in MD and MD/PhD training, but their advancement in academic biomedical science is reduced at every career milestone thereafter. Women are significantly underrepresented even at the earliest points in the PhD pipeline, particularly in fields outside of biology. This is a troubling statistic that negatively impacts the talent pool and exacerbates career inequity in all areas of biomedical research. The major biomedical research themes that will command our attention in the 21st century—neuroscience, cardiovascular disease, oncology—will require large team science efforts integrating a diversity of scientific disciplines, including biology, engineering, sociology, chemistry, and medicine. These scientific teams must also integrate diversity in gender, race, and ethnicity to enrich and add value to their discoveries and to better serve a diverse and multicultural society. This editorial reviews factors that may actively impede women's participation in biomedical research, at the level of graduate and postgraduate training, in their opportunities for career advancement in the professoriate, and in their competitiveness in securing research support.
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      References

        • Schiebinger L.
        Scientific research must take gender into account.
        Nature. 2014; 507: 9
        • Pololi L.H.
        • Civian J.T.
        • Brennan R.T.
        • Dottolo A.L.
        • Krupat E.
        Experiencing the culture of academic medicine: gender matters, a national study.
        J Gen Intern Med. 2013; 28: 201-207
        • Corrice A.M.
        Unconscious bias in faculty and leadership recruitment: a literature review. Association of American Medical Colleges.
        Analysis in Brief. 2009; 9: 2
        • Spencer S.J.
        • Steele C.M.
        • Quinn D.M.
        Stereotype threat and women's math performance.
        J Exp Soc Psychol. 1998; 35: 4-28
        • Johns M.
        • Schmader T.
        • Martens A.
        Knowing is half the battle: teaching stereotype threat as a means of improving women's math performance.
        Psychol Sci. 2005; 16: 175-179
        • Thoman D.B.
        • Smith J.L.
        • Brown E.R.
        • Chase J.
        • Lee J.Y.
        Beyond performance:a motivational experiences model of stereotype threat.
        Educ Psychol Rev. 2013; 25: 211-243
        • Burgess D.J.
        • Joseph A.
        • van Ryn M.
        • Carnes M.
        Does stereotype threat affect women in academic medicine?.
        Acad Med. 2012; 87: 506-512
        • Leadley J.
        • Magrane D.
        • Lang J.
        • Pham T.
        Women in U.S. academic medicine: statistics and benchmarking report, 2007-2008.
        American Association of Medical Colleges, Washington, DC2008
        • Rudman L.A.
        • Kilianski S.E.
        Implicit and explicit attitudes toward female authority.
        Pers Soc Psychol Bull. 2000; 26: 1315-1328
        • Heilman M.E.
        • Wallen A.S.
        • Fuchs D.
        • Tamkins M.M.
        Penalties for success: reactions to women who succeed at male gender-typed tasks.
        J Appl Psychol. 2004; 89: 416-427
        • Wayne N.L.
        • Vermillion M.
        • Uijtdehaage S.
        Gender differences in leadership amongst first-year medical students in the small-group setting.
        Acad Med. 2010; 85: 1276-1281
        • Andriole D.A.
        • Whelan A.J.
        • Jeffe D.B.
        Characteristics and career intentions of the emerging MD/PhD workforce.
        JAMA. 2008; 300: 1165-1173
        • Martinez E.D.
        • Botos J.
        • Dohoney K.M.
        • Geiman T.M.
        • Kolla S.S.
        • Olivera A.
        • et al.
        Falling off the academic bandwagon. Women are more likely to quit at the postdoc to principal investigator transition.
        EMBO Rep. 2007; 8: 977-981
        • Zhuge Y.
        • Kaufman J.
        • Simeone D.M.
        • Chen H.
        • Velazquez O.C.
        Is there still a glass ceiling for women in academic surgery?.
        Ann Surg. 2011; 253: 637-643
        • Jolliff L.
        • Leadley J.
        • Coakley E.
        • Sloane R.A.
        Women in U.S. academic medicine and science: statistics and benchmarking report 2011-2012.
        Association of American Medical Colleges, Washington, DC2012: 1-59
        • Mayer A.P.
        • Blair J.E.
        • Ko M.G.
        • Hayes S.N.
        • Chang Y.H.
        • Caubet S.L.
        • et al.
        Gender distribution of U.S. medical school faculty by academic track type.
        Acad Med. 2014; 89: 312-317
        • Jagsi R.
        • Griffith K.A.
        • Stewart A.
        • Sambuco D.
        • DeCastro R.
        • Ubel P.A.
        Gender differences in the salaries of physician researchers.
        JAMA. 2012; 307: 2410-2417
        • Borges N.J.
        • Navarro A.M.
        • Grover A.C.
        Women physicians: choosing a career in academic medicine.
        Acad Med. 2012; 87: 105-114
        • Moss-Racusin C.A.
        • Dovidio J.F.
        • Brescoll V.L.
        • Graham M.J.
        • Handelsman J.
        Science faculty's subtle gender biases favor male students.
        Proc Natl Acad Sci U S A. 2012; 109: 16474-16479
        • Tesch B.J.
        • Wood H.M.
        • Helwig A.L.
        • Nattinger A.B.
        Promotion of women physicians in academic medicine. Glass ceiling or sticky floor?.
        JAMA. 1995; 273: 1022-1025
        • Bussey-Jones J.
        • Bernstein L.
        • Higgins S.
        • Malebranche D.
        • Paranjape A.
        • Genao I.
        • et al.
        Repaving the road to academic success: the IMeRGE approach to peer mentoring.
        Acad Med. 2006; 81: 674-679
        • Pohlhaus J.R.
        • Jiang H.
        • Wagner R.M.
        • Schaffer W.T.
        • Pinn V.W.
        Sex differences in application, success, and funding rates for NIH extramural programs.
        Acad Med. 2011; 86: 759-767
        • Waisbren S.E.
        • Bowles H.
        • Hasan T.
        • Zou K.H.
        • Emans S.J.
        • Goldberg C.
        • et al.
        Gender differences in research grant applications and funding outcomes for medical school faculty.
        J Womens Health (Larchmt). 2008; 17: 207-214
        • Hosek S.D.
        • Cox A.G.
        • Ghosh-Dastidar B.
        • et al.
        Gender differences in major federal external grant programs.
        RAND Infrastructure, Safety, and Environment, Santa Monica, CA2005: 1-71
        • Nattinger A.B.
        Promoting the career development of women in academic medicine.
        Arch Intern Med. 2007; 167: 323-324
        • Jagsi R.
        • Motomura A.R.
        • Griffith K.A.
        • Rangarajan S.
        • Ubel P.A.
        Sex differences in attainment of independent funding by career development awardees.
        Ann Intern Med. 2009; 151: 804-811
        • Ginther D.K.
        • Schaffer W.T.
        • Schnell J.
        • Masimore B.
        • Liu F.
        • Haak L.L.
        • et al.
        Race, ethnicity, and NIH research awards.
        Science. 2011; 333: 1015-1019
        • Handelsman J.
        • Cantor N.
        • Carnes M.
        • Denton D.
        • Fine E.
        • Grosz B.
        • et al.
        Careers in science. More women in science.
        Science. 2005; 309: 1190-1191
        • National Science Board
        Science and engineering indicators 2012.
        National Science Foundation, Arlington, VA2012
        • National Science Foundation, Division of Science Resources Statistics 2008
        Thirty three years of women in S&E faculty positions.
        National Science Foundation, Arlington, VA2014
        • Sheltzer J.M.
        • Smith J.C.
        Elite male faculty in the life sciences employ fewer women.
        Proc Natl Acad Sci U S A. 2014; 111: 10107-10112
        • Woodruff T.K.
        Sex, equity, and science.
        Proc Natl Acad Sci U S A. 2014; 111: 5063-5064
        • Kim A.M.
        • Tingen C.M.
        • Woodruff T.K.
        Sex bias in trials and treatment must end.
        Nature. 2010; 465: 688-689
        • Yang X.
        • Schadt E.E.
        • Wang S.
        • Wang H.
        • Arnold A.P.
        • Ingram-Drake L.
        • et al.
        Tissue-specific expression and regulation of sexually dimorphic genes in mice.
        Genome Res. 2006; 16: 995-1004
        • Yoon D.Y.
        • Manusukhan N.A.
        • Stubbs V.C.
        • Helenowski I.B.
        • Woodruff T.K.
        • Kibbe M.R.
        Sex bias exists in basic science and translational surgical research..
        Surgery. 2014; 156: 508-516
        • Clayton J.A.
        • Collins F.S.
        Policy: NIH to balance sex in cell and animal studies.
        Nature. 2014; 509: 282-283
        • Pinnow E.
        • Herz N.
        • Loyo-Berrios N.
        • Tarver M.
        Enrollment and monitoring of women in post-approval studies for medical devices mandated by the Food and Drug Administration.
        J Womens Health (Larchmt). 2014; 23: 218-223
        • Kim E.S.
        • Carrigan T.P.
        • Menon V.
        Enrollment of women in National Heart, Lung, and Blood Institute-funded cardiovascular randomized controlled trials fails to meet current federal mandates for inclusion.
        J Am Coll Cardiol. 2008; 52: 672-673
        • Harris D.J.
        • Douglas P.S.
        Enrollment of women in cardiovascular clinical trials funded by the National Heart, Lung, and Blood Institute.
        N Engl J Med. 2000; 343: 475-480
        • Westring A.F.
        • Speck R.M.
        • Dupuis Sammel M.
        • Scott P.
        • Conant E.F.
        • Tuton L.W.
        • et al.
        Culture matters: the pivotal role of culture for women's careers in academic medicine.
        Acad Med. 2014; 89: 658-663
        • Demmy T.L.
        • Kivlahan C.
        • Stone T.T.
        • Teague L.
        • Sapienza P.
        Physicians' perceptions of institutional and leadership factors influencing their job satisfaction at one academic medical center.
        Acad Med. 2002; 77: 1235-1240
        • Lowenstein S.R.
        • Fernandez G.
        • Crane L.A.
        Medical school faculty discontent: prevalence and predictors of intent to leave academic careers.
        BMC Med Educ. 2007; 7: 37
        • Westring A.F.
        • Speck R.M.
        • Sammel M.D.
        • Scott P.
        • Tuton L.W.
        • Grisso J.A.
        • et al.
        A culture conducive to women's academic success: development of a measure.
        Acad Med. 2012; 87: 1622-1631
        • Fried L.P.
        • Francomano C.A.
        • MacDonald S.M.
        • Wagner E.M.
        • Stokes E.J.
        • Carbone K.M.
        • et al.
        Career development for women in academic medicine: Multiple interventions in a department of medicine.
        JAMA. 1996; 276: 898-905
        • National Institutes of Health
        Research supplements to promote re-entry into biomedical and behavioral research careers.
        National Institutes of Health, Bethesda, MD2010
        • National Institutes of Health
        Research supplements to promote diversity in health-related research.
        National Institutes of Health, Bethesda, MD2012
        • National Institutes of Health
        NIH Policy Concerning Career Development (K) awards: leave, temporary adjustments to percent effort, and part-time institutional appointments.
        National Institutes of Health, Bethesda, MD2011
        • National Institutes of Health
        Research on causal factors and interventions that promote and support the careers of women in biomedical and behavioral science and engineering (R01).
        National Institutes of Health, Bethesda, MD2008
        • National Institutes of Health
        NIH Working Group on Women in Biomedical Careers.
        National Institutes of Health, Bethesda, MD2010