Background
Peritoneal dissemination and positive peritoneal lavage cytology are associated with
poor prognosis in colorectal cancer. Carcinoembryonic antigen (CEA) messenger RNA
(mRNA) is often used as a marker to detect micrometastases. We aimed to evaluate the
prognostic significance of CEA mRNA in the peritoneal lavage of colon cancer patients.
Methods
Colon cancer patients (n = 201) who underwent curative operative resection between August 2009 and February
2013 were enrolled. CEA mRNA in peritoneal lavage was measured using the transcription-reverse
transcription concerted method, a quantitative RNA amplification method. The correlation
between CEA mRNA and overall and peritoneal recurrence-free survival was evaluated.
Results
Positive CEA mRNA in peritoneal lavage was an independent risk factor for overall
recurrence-free survival in colon cancer (P < .0001). Positive CEA mRNA was a risk factor for poorer overall recurrence in stage
II and III patients (P = .04 and P = .02, respectively). Moreover, among stage III patients with positive CEA mRNA,
the postoperative chemotherapy group had significantly lower overall and peritoneal
recurrence rates than the no postoperative chemotherapy group (P = .001).
Conclusion
Positive CEA mRNA in peritoneal lavage was associated with high overall recurrence
rates in stage II and III colon cancer. Further study is necessary to determinate
the efficacy of aggressive postoperative chemotherapy for stage II and III colon cancer
patients with positive CEA mRNA.
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Article info
Publication history
Published online: October 10, 2014
Accepted:
September 5,
2014
Footnotes
Financial Disclosure: None reported.
Identification
Copyright
© 2015 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
