Background
Inflammation plays a crucial role in tumor growth, metastasis, and survival. The preoperative
platelet-to-lymphocyte ratio (PLR) has been reported as a significant prognostic indicators
in several digestive malignancies. Our objective was to evaluate whether preoperative
PLR is a prognostic index in resected pancreatic ductal adenocarcinoma.
Methods
Data from 131 patients who underwent pancreatic resection for pancreatic ductal adenocarcinoma
were available from a prospectively maintained database. The patients were divided
into groups according to a preoperative PLR of <150 or ≥150. Survival data were analyzed.
Results
In univariate and multivariate analyses, a preoperative PLR of ≥150 was a significant
and independent risk factor for cancer recurrence and poor survival, respectively
(disease-free survival [DFS]; P= .0014, P = .047; OS, P ≤ .01each). Similarly, lymph node metastasis, and moderate or poor differentiation
were independent risk factors for cancer recurrence, whereas tumor diameter, positive
surgical margin, and moderate or poor differentiation were independent risk factors
for poor patient survival (P ≤ .05 each).
Conclusion
The preoperative PLR in patients with pancreatic ductal adenocarcinoma was an independent
predictor in DFS and overall survival after elective resection. Measurement of the
PLR may help decision making in the postoperative management of patients with pancreatic
ductal adenocarcinoma.
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Article info
Publication history
Published online: May 29, 2015
Accepted:
March 3,
2015
Identification
Copyright
© 2015 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
