Background
At 12 months after a parathyroid operation, we expect cured patients to have biochemical
profiles similar to those of healthy individuals. The aim of the current study was
to compare the biochemical characteristics patients at 12 months after parathyroidectomy
for primary sporadic hyperparathyroidism with those of healthy controls.
Methods
A total of 547 patients who underwent parathyroid neck operation for primary sporadic
hyperparathyroidism from 2000–2014 were analyzed. A control group consisted of 74
healthy subjects. Calcium and parathyroid hormone were collected perioperatively.
Graphic plots of the relationship between calcium versus parathyroid hormone (95%
confidence intervals) were used to compare the biochemical profiles of patients after
parathyroid operation and controls.
Results
Preoperatively, patients with primary sporadic hyperparathyroidism had a calcium level
of 10.9 ± 0.5 mg/dL and parathyroid hormone level of 124.4 ± 68.5 pg/dL vs controls'
values of 9.2 ± 0.3 mg/dL and 34.4 ± 13.4 pg/dL, respectively. Before operation, all
primary sporadic hyperparathyroidism patients had calcium versus parathyroid hormone
values outside the normal zone. At 12 months after operation, 335 (69%) patients showed
normalization of the chemical profile; 13 (2.7%) had absolute elevation of calcium
and parathyroid hormone, reflecting persistent disease; 2 (0.4%) patients had hypoparathyroidism
after subtotal parathyroidectomy; and 149 (31%) had calcium and parathyroid hormone
values outside the normal zone, not fitting into the above categories. There were
no marked differences between patients with simple adenoma those with multiple-gland
disease.
Conclusion
Longer follow-up might be needed for patients after parathyroid operation to confirm
stabilization of biochemical profiles.
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Article info
Publication history
Published online: November 29, 2016
Accepted:
October 7,
2016
Identification
Copyright
Published by Elsevier Inc.
