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Healthcare| Volume 165, ISSUE 3, P501-509, March 2019

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Care fragmentation is associated with increased short-term mortality during postoperative readmissions: A systematic review and meta-analysis

Published:January 09, 2019DOI:https://doi.org/10.1016/j.surg.2018.08.021

      Background

      Recent trends toward regionalization of complex surgical procedures may increase the risk for care fragmentation during readmissions. Conflicting conclusions have been reported regarding risk factors and consequences of nonindex readmissions (ie, readmission to a separate hospital than the one where surgery was originally performed). We seek to perform a comprehensive review of existing literature.

      Methods

      Four electronic databases were searched to identify all eligible studies examining the risk factors and outcomes of postoperative nonindex readmission. The pooled odds ratio and 95% confidence interval were calculated using a random-effects model.

      Results

      A total of 444 studies were retrieved from database searches and 23 were included after applying eligibility criteria. Nonindex readmissions constituted 10%–47% of 30-day readmissions. Risk factors for nonindex readmission predominantly represented proxy variables for patient care access that may not be modifiable, such as residing in a location further away from the original hospital, being older in age, living in rural areas, and having lower income. Nonindex readmissions occurred more commonly under urgent conditions. Ten of the 14 studies that employed short-term mortality as the primary outcome concluded that nonindex readmissions were significantly associated with higher mortality after adjusting for available confounders.

      Conclusion

      The findings of the current study suggest that nonindex readmission is a common phenomenon after surgery and is associated with increased mortality. Further studies are required to evaluate whether enhancing health information continuity between hospitals would be helpful for mitigating the adverse consequences of care fragmentation.
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      References

        • Brooke BS
        • Goodney PP
        • Kraiss LW
        • Gottlieb DJ
        • Samore MH
        • Finlayson SRG
        Readmission destination and risk of mortality after major surgery: An observational cohort study.
        Lancet. 2015; 386: 884-895
        • Burke RE
        • Jones CD
        • Hosokawa P
        • Glorioso TJ
        • Coleman EA
        • Ginde AA
        Influence of nonindex hospital readmission on length of stay and mortality.
        Med Care. 2018; 56: 85-90
        • Saunders RS
        • Fernandes-Taylor S
        • Kind AJH
        • et al.
        Rehospitalization to primary versus different facilities following abdominal aortic aneurysm repair.
        J Vasc Surg. 2014; 59 (1510.e1–2): 1502-1510
        • Stitzenberg KB
        • Chang Y
        • Smith AB
        • Meyers MO
        • Nielsen ME
        Impact of location of readmission on outcomes after major cancer surgery.
        Ann Surg Oncol. 2017; 24: 319-329
        • Tsai TC
        • Orav J
        • Jha AK
        Care fragmentation in the post discharge period: Surgical readmissions, distance of travel, and postoperative mortality.
        J Vasc Surg. 2015; 61: 1653
        • Zheng C
        • Habermann E
        • Langan RC
        • et al.
        Fragmentation of care after surgical discharge: Non-index readmission after major cancer surgery.
        Am Coll Surg. 2016; 222 (e2): 780-789
        • Chappidi MR
        • Kates M
        • Stimson CJ
        • Johnson MH
        • Pierorazio PM
        • Bivalacqua TJ
        Causes, timing, hospital costs and perioperative outcomes of index vs nonindex hospital readmissions after radical cystectomy: Implications for regionalization of care.
        J Urol. 2017; 197: 296-301
        • Glebova NO
        • Hicks CW
        • Taylor R
        • et al.
        Readmissions after complex aneurysm repair are frequent, costly, and primarily at nonindex hospitals.
        J Vasc Surg. 2014; 60: 1429-1437
        • Graboyes EM
        • Kallogjeri D
        • Saeed MJ
        • Olsen MA
        • Nussenbaum B
        Postoperative care fragmentation and thirty-day unplanned readmissions after head and neck cancer surgery.
        Laryngoscope. 2017; 127: 868-874
        • Havens JM
        • Olufajo OA
        • Tsai TC
        • et al.
        Hospital factors associated with care discontinuity following emergency general surgery.
        JAMA Surg. 2017; 152: 242-249
        • Hua M
        • Gong MN
        • Miltiades A
        • Wunsch H
        Outcomes after rehospitalization at the same hospital or a different hospital following critical illness.
        Am J Respir Crit Care Med. 2017; 195: 1486-1493
        • Justiniano C
        • Xu Z
        • Becerra A
        • et al.
        Surgeon care fragmentation during readmission after colorectal surgery is associated with increased mortality: Continuity of care counts.
        J Am Coll Surg. 2017; 225: S1267
        • Kothari AN
        • Loy VM
        • Brownlee SA
        • et al.
        Adverse effect of post-discharge care fragmentation on outcomes after readmissions after liver transplantation.
        J Am Coll Surg. 2017; 225: 62-67
        • Pak JS
        • Lascano D
        • Kabat DH
        • et al.
        Patterns of care for readmission after radical cystectomy in New York State and the effect of care fragmentation.
        Urol Oncol Semin Orig Investig. 2015; 33 (e13–9): 426
        • Ghaferi AA
        • Birkmeyer JD
        • Dimick JB
        Hospital volume and failure to rescue with high-risk surgery.
        Med Care. 2011; 49: 1076-1081
        • Ghaferi AA
        • Birkmeyer JD
        • Dimick JB
        Complications, failure to rescue, and mortality with major inpatient surgery in medicare patients.
        Ann Surg. 2009; 250: 1029-1034
        • Hannan EL
        • O'Donnell JF
        • Kilburn H
        • Bernard HR
        • Yazici A
        Investigation of the relationship between volume and mortality for surgical procedures performed in New York State hospitals.
        JAMA. 1989; 262: 503-510
        • Begg CB
        • Cramer LD
        • Hoskins WJ
        • Brennan MF
        Impact of hospital volume on operative mortality for major cancer surgery.
        JAMA. 1998; 280: 1747-1751
        • Luft HS
        • Bunker JP
        • Enthoven AC
        Should operations be regionalized?.
        N Engl J Med. 1979; 301: 1364-1369
        • Hollenbeck BK
        • Miller DC
        • Wei JT
        • Montie JE
        Regionalization of care: centralizing complex surgical procedures.
        Nat Clin Pract Urol. 2005; 2: 461
        • Brooke BS
        • Goodney PP
        • Kraiss LW
        • Gottlieb DJ
        • Samore MH
        • Finlayson SRG
        Readmission destination and risk of mortality after major surgery: an observational cohort study.
        Lancet. 2015; 386: 884-895
        • Tsai TC
        • Orav EJ
        • Jha AK
        Care fragmentation in the postdischarge period: surgical readmissions, distance of travel, and postoperative mortality.
        JAMA Surg. 2015; 150: 59-64
        • Adler-Milstein J
        • DesRoches CM
        • Jha AK
        Health information exchange among US hospitals.
        Am J Manag Care. 2011; 17: 761-768
        • Weinberg D
        • Gittell J
        • Lusenhop RW
        • Kautz CM
        • Wright J
        Beyond our walls: Impact of patient and provider coordination across the continuum on outcomes for surgical patients.
        Health Serv Res. 2007; 42: 7-24
        • Lawson EH
        • Hall BL
        • Louie R
        • et al.
        Association between occurrence of a postoperative complication and readmission: implications for quality improvement and cost savings.
        Ann Surg. 2013; 258: 10-18
        • Fisher A V
        • Fernandes-Taylor S
        • Campbell-Flohr SA
        • et al.
        30-day readmission after pancreatic resection: A systematic review of the literature and meta-analysis.
        Ann Surg. 2017; 266: 242-250
        • Damle RN
        • Alavi K
        Risk factors for 30-d readmission after colorectal surgery: a systematic review.
        J Surg Res. 2016; 200: 200-207
        • Gore JL
        • Lai J
        • Gilbert SM
        Urologic Diseases in America Project. Readmissions in the postoperative period following urinary diversion.
        World J Urol. 2011; 29: 79-84
        • Havens JM
        • Olufajo OA
        • Tsai TC
        • et al.
        Hospital factors associated with care discontinuity following emergency general surgery.
        JAMA Surg. 2017; 152: 242-249
      1. Cochrane. Cochrane handbook for systematic reviews of interventions Web site. http://community.cochrane.org/book_pdf/764. Accessed March 8, 2018.

        • Sterne JA
        • Hernán MA
        • Reeves BC
        • et al.
        ROBINS-I: A tool for assessing risk of bias in non-randomised studies of interventions.
        BMJ. 2016; 355: i4919
        • Tosoian J
        • Hicks C
        • Cameron J
        • et al.
        Tracking early readmission after pancreatectomy to index and nonindex institutions: A more accurate assessment of readmission.
        JAMA Surg. 2015; 150: 152-158
        • Zheng C
        • Habermann E
        • Langan RC
        • et al.
        Fragmentation of care after surgical discharge: non-index readmission after major cancer surgery.
        Am Coll Surg. 2016; 222: 780-789
        • Justiniano C
        • Xu Z
        • Becerra AZ
        • et al.
        Long-term deleterious impact of surgeon care fragmentation after colorectal surgery on survival: continuity of care continues to count.
        Dis Colon Rectum. 2017; 60: 1147-1154
        • Graboyes EM
        • Kallogjeri D
        • Saeed MJ
        • Olsen MA
        • Nussenbaum B
        30-day hospital readmission following otolaryngology surgery: analysis of a state inpatient database.
        Laryngoscope. 2017; 127: 337-345
        • Cloyd JM
        • Huang L
        • Ma Y
        • Rhoads KF
        Predictors of readmission to non-index hospitals after colorectal surgery.
        Am J Surg. 2017; 213: 18-23
        • Ryoo JJ
        • Kunitake H
        • Frencher SK
        • et al.
        Continuity of care: Readmission to the same hospital following gastric cancer resection.
        J Am Coll Surg. 2009; 209: S16-S17
        • Chappidi MR
        • Kates M
        • Stimson CJ
        • Bivalacqua TJ
        • Pierorazio PM
        Quantifying nonindex hospital readmissions and care fragmentation after major urological oncology surgeries in a nationally representative sample.
        J Urol. 2017; 197: 235-240
        • Dexter F
        • Epstein R
        • Sun EC
        • Lubarsky DA
        • Dexter EU
        Readmissions to different hospitals after common surgical procedures and consequences for implementation of perioperative surgical home programs.
        Anesth Analg. 2017; 125: 943-951
        • Rattan R
        • Parreco J
        • Lindenmaier L
        • Yeh DD
        • Zakrison TL
        • Pust GD
        • et al.
        Underestimation of unplanned readmission after colorectal surgery: A national analysis.
        J Am Coll Surg. 2018; 226: 382-390
        • Tosoian JJ
        • Hicks CW
        • Cameron JL
        • et al.
        Tracking early readmission after pancreatectomy to index and nonindex institutions.
        JAMA Surg. 2015; 150: 152
        • Havens JM
        • Olufajo OA
        • Tsai TC
        • et al.
        Hospital factors associated with care discontinuity following emergency general surgery.
        JAMA Surg. 2017; 152: 242-249
        • Yermilov I
        • Bentrem D
        • Sekeris E
        • et al.
        Readmissions following pancreaticoduodenectomy for pancreas cancer: A population-based appraisal.
        Ann Surg Oncol. 2009; 16: 554-561
        • Chappidi MR
        • Kates M
        • Stimson CJ
        • Johnson MH
        • Pierorazio PM
        • Bivalacqua TJ
        Causes, timing, hospital costs and perioperative outcomes of index vs nonindex hospital readmissions after radical cystectomy: Implications for regionalization of care.
        J Urol. 2017; 197: 296-301
        • Brooke BS
        • Goodney PP
        • Kraiss LW
        • Gottlieb DJ
        • Samore MH
        • Finlayson SRG
        Readmission destination and risk of mortality after major surgery: an observational cohort study.
        Lancet. 2015; 386: 884-895
        • Baker R
        • Mainous AG
        • Gray DP
        • Love MM
        Exploration of the relationship between continuity, trust in regular doctors and patient satisfaction with consultations with family doctors.
        Scand J Prim Health Care. 2003; 21: 27-32
        • Bekelis K
        • Roberts DW
        • Zhou W
        • Skinner JS
        Fragmentation of care and the use of head computed tomography in patients with ischemic stroke.
        Circ Cardiovasc Qual Outcomes. 2014; 7: 430-436
        • de Brantes F
        • Rosenthal MB
        • Painter M
        Building a bridge from fragmentation to accountability—the Prometheus Payment model.
        N Engl J Med. 2009; 361: 1033-1036
        • McAlister FA
        • Youngson E
        • Kaul P
        Patients With heart failure readmitted to the original hospital have better outcomes than those readmitted elsewhere.
        J Am Heart Assoc. 2017; 6: e004892
        • Chien CF
        • Steinwachs DM
        • Lehman A
        • Fahey M
        • Skinner EA
        Provider continuity and outcomes of care for persons with schizophrenia.
        Ment Health Serv Res. 2000; 2: 201-211
        • Flynn SP
        Continuity of care during pregnancy: the effect of provider continuity on outcome.
        J Fam Pract. 1985; 21: 375-380
        • Tran TT
        • Kaneva P
        • Mayo NE
        • Fried GM
        • Feldman LS
        Short-stay surgery: what really happens after discharge?.
        Surgery. 2014; 156: 20-27
        • Tsai TC
        • Orav EJ
        • Jha AK
        Care fragmentation in the postdischarge period.
        JAMA Surg. 2015; 150: 59
        • Cloyd JM
        • Huang L
        • Ma Y
        • Rhoads KF
        Predictors of readmission to non-index hospitals after colorectal surgery.
        Am J Surg. 2017; 213: 18-23
        • Kash BA
        • Baek J
        • Davis E
        • Champagne-Langabeer T
        • Langabeer JR
        Review of successful hospital readmission reduction strategies and the role of health information exchange.
        Int J Med Inform. 2017; 104: 97-104
        • Adler-Milstein J
        • Jha AK
        Health information exchange among US hospitals: who's in, who's out, and why?.
        Healthcare. 2014; 2: 26-32
        • Forster AJ
        • Murff HJ
        • Peterson JF
        • Gandhi TK
        • Bates DW
        The incidence and severity of adverse events affecting patients after discharge from the hospital.
        Ann Intern Med. 2003; 138: 161-167
        • Sinvani LD
        • Beizer J
        • Akerman M
        • et al.
        Medication reconciliation in continuum of care transitions: a moving target.
        J Am Med Dir Assoc. 2013; 14: 668-672
        • Axon RN
        • Cole L
        • Moonan A
        • et al.
        Evolution and initial experience of a statewide care transitions quality improvement collaborative: preventing avoidable readmissions Together.
        Popul Health Manag. 2016; 19: 4-10
        • Vest JR
        • Kern LM
        • Silver MD
        • Kaushal R
        • investigators HITEC
        The potential for community-based health information exchange systems to reduce hospital readmissions.
        J Am Med Inform Assoc. 2015; 22: 435-442
        • Staggers N
        • Clark L
        • Blaz JW
        • Kapsandoy S
        Why patient summaries in electronic health records do not provide the cognitive support necessary for nurses’ handoffs on medical and surgical units: insights from interviews and observations.
        Health Informatics J. 2011; 17: 209-223
        • Turner JP
        • Rodriguez HE
        • Daskin MS
        • Mehrotra S
        • Speicher P
        • DaRosa DA
        Overcoming obstacles to resident-patient continuity of care.
        Ann Surg. 2012; 255: 618-622
        • Bekelis K
        • Missios S
        • MacKenzie TA
        Continuity of care and 30-day readmission for patients evaluated in the emergency room after cerebral aneurysm treatment.
        J Neurointerv Surg. 2016; 8: 1203-1206
        • Reid R
        • Phd M
        • Haggerty Phd J
        • Mckendry Ma R
        Defusing the confusion: concepts and measures of continuity of healthcare final report.
        (Accessed March 13, 2018)