Postoperative acute pancreatitis after a pancreatic resection: A new entity?

Published:December 01, 2020DOI:
      This miniseries is designed to introduce and discuss this intriguing new entity, postoperative acute pancreatitis (POAP), occurring after a pancreatic resection. We are publishing four papers, each of which discusses this new entity from a different perspective: prevalence, definition, and diagnosis. Pay attention to several topics that remain highly debated, especially the definition, because there have been several different ones! Other controversial issues include the diagnosis, and, specifically, the necessity of cross-sectional imaging for the diagnosis and the potential etiopathogenesis. Other fascinating facets include prevalence (which is, at least to us, surprisingly high), relationship to postoperative hyperamylasemia, and whether this condition is a localized parenchymal injury at the pancreaticoenterostomy after a pancreatoduodenectomy or at the staple line/stump closure after a distal pancreatectomy. Furthermore, is POAP a global parenchyma inflammation or is it really a response to parenchymal injury with release of cytokines? Lastly, our miniseries contemplates why postoperative pancreatic fistulas are more common in patients who develop POAP.
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