Abstract
Background
Despite the known association between frailty and postoperative morbidity, the use
of preoperative frailty in surgical practice remains limited. We sought to develop
a risk tool to predict postoperative increase in functional dependence.
Methods
Patients of ≥65 years in the National Surgical Quality Improvement Project database
who had a primary hepatopancreatic surgery between 2015 and 2019 were used to identify
predictors of increased dependence and development of a simplified tool to calculate
the risk stratification score for increased discharge care level (https://ktsahara.shinyapps.io/care_discharge/).
Results
Among 31,338 patients who underwent primary hepatopancreatic surgery, 4,259 (13.6%)
had an increased level of care at discharge compared to their preadmission care. Patients
with increased discharge care had a higher proportion of patients with a modified
frailty index of at least 2 (n = 1496; 35.1%) compared with individuals with unchanged care (n = 6,760; 25.0%). In addition, 12.3% (n = 3,858) were discharged to a skilled nursing or rehabilitation facility. Of note,
the odds of increased care at discharge were increased by 1.41 (95% confidence interval:
1.32–1.50), 1.11 (95% confidence interval :1.11–1.12), and 1.95 (95% confidence interval:1.86–2.04)
times with every unit increase in modified frailty index, age beyond 65 years, and
the number of in-hospital complications, respectively. Area under receiver operative
curve for the parsimonious model used to develop the risk calculator was 0.7486 (95%
confidence interval: 0.7405–0.7566) (all P < .001).
Conclusion
Approximately, 1 in 7 patients required an increased level of care at the time of
discharge compared with their preadmission status. A simplified web-based risk tool
can be used in clinical practice as a surgical decision aid in post-discharge planning
after complex elective surgery.
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to SurgeryAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Surgery for an ageing population.Br J Surg. 2016; 103: e7-e9
- Tailoring surgery to elderly patients with cancer.Br J Surg. 2016; 103: e10-e11
- Frailty and cancer: Implications for oncology surgery, medical oncology, and radiation oncology.CA Cancer J Clin. 2017; 67: 362-377
- Spending on care after surgery driven by choice of care settings instead of intensity of services.Health Aff Proj Hope. 2017; 36: 83-90
- Assessing post-discharge costs of hepatopancreatic surgery: an evaluation of Medicare expenditure.Surgery. 2020; 167: 978-984
- Skilled nursing facility (SNF) utilization and impact of SNF star-quality ratings on outcomes following hepatectomy among Medicare beneficiaries.HPB. 2020; 22: 109-115
- Impact of skilled nursing facility quality on postoperative outcomes after pancreatic surgery.Surgery. 2019; 166: 1-7
- Preoperative frailty increases risk of nonhome discharge after elective vascular surgery in home-dwelling patients.Ann Vasc Surg. 2016; 35: 19-29
- Trends in discharge disposition following hepatectomy for hepatocellular carcinoma among Medicare beneficiaries.J Gastrointest Surg. 2021; 25: 2842-2850
- Implications of aging in surgical oncology.Cancer J. 2005; 11: 488-494
- Impact of sarcopenia on outcomes following resection of pancreatic adenocarcinoma.J Gastrointest Surg. 2012; 16: 1478-1486
- Prevalence of frailty in community-dwelling older persons: a systematic review.J Am Geriatr Soc. 2012; 60: 1487-1492
- Cancer statistics, 2017.CA Cancer J Clin. 2017; 67: 7-30
- Prevalence and 10-year outcomes of frailty in older adults in relation to deficit accumulation.J Am Geriatr Soc. 2010;https://agsjournals.onlinelibrary.wiley.com/doi/10.1111/j.1532-5415.2010.02764.xDate accessed: August 13, 2021
- Frailty and the prediction of negative health outcomes: a meta-analysis.J Am Med Dir Assoc. 2016; 17: 1163.e1-1163.e17
- Frailty in elderly people.Lancet. 2013; 381: 752-762
- The prevalence and outcomes of frailty in older cancer patients: a systematic review.Ann Oncol. 2015; 26: 1091-1101
- Frailty as a predictor of surgical outcomes in older patients.J Am Coll Surg. 2010; 210: 901-908
- A modified frailty index to assess morbidity and mortality after lobectomy.J Surg Res. 2013; 183: 40-46
- Simplified frailty index as a predictor of adverse outcomes in total hip and knee arthroplasty.J Arthroplasty. 2016; 31: 2389-2394
- Frailty Index is a significant predictor of complications and mortality after surgery for adult spinal deformity.Spine. 2016; 41: E1394-E1401
- Measurement and validation of frailty as a predictor of outcomes in women undergoing major gynaecological surgery.BJOG Int J Obstet Gynaecol. 2016; 123: 455-461
- Prevalence, attributes, and outcomes of fitness and frailty in community-dwelling older adults: report from the Canadian Study of Health and Aging.J Gerontol Ser A. 2004; 59: 1310-1317
- New 5-Factor Modified Frailty Index using American College of Surgeons NSQIP data.J Am Coll Surg. 2018; 226: 173-181.e8
- The Brisbane 2000 terminology of liver anatomy and resections. HPB 2000;2:333–339.HPB. 2002; 4: 99-339
- Evaluation of the ACS NSQIP Surgical Risk Calculator in elderly patients undergoing hepatectomy for hepatocellular carcinoma.J Gastrointest Surg. 2020; 24: 551-559
- The power of the National Surgical Quality Improvement Program: achieving a zero pneumonia rate in general surgery patients.Perm J. 2012; 16: 39-45
- Association between preadmission frailty and care level at discharge in older adults undergoing emergency laparotomy.Br J Surg. 2020; 107: 218-226
- Diagnostic methods I: sensitivity, specificity, and other measures of accuracy.Kidney Int. 2009; 75: 1257-1263
- Clinical and morphometric parameters of frailty for prediction of mortality following hepatopancreaticobiliary surgery in the elderly.Br J Surg. 2016; 103: e83-e92
- Frailty as a risk predictor of morbidity and mortality following liver surgery.J Gastrointest Surg. 2017; 21: 822-830
- Fear of loss of independence and nursing home admission in older Australians.Health Soc Care Community. 2007; 15: 212-220
- Predictors and outcomes of nonroutine discharge after hepatopancreatic surgery.Surgery. 2019; 165: 1128-1135
- Hot spotting surgical patients undergoing hepatopancreatic procedures.HPB. 2019; 21: 765-772
- Hospice utilization among Medicare beneficiaries dying from pancreatic cancer.J Surg Oncol. 2019; 120: 624-631
- Predictors of extended length of stay, discharge to inpatient rehab, and hospital readmission following elective lumbar spine surgery: introduction of the Carolina-Semmes Grading Scale.J Neurosurg Spine. 2017; 27: 382-390
- Using the FRAIL scale to compare pre-existing demographic lifestyle and medical risk factors between non-frail, pre-frail and frail older adults accessing primary health care: a cross-sectional study.PeerJ. 2020; 8e10380
- Frailty and pre-frailty in middle-aged and older adults and its association with multimorbidity and mortality: a prospective analysis of 493 737 UK Biobank participants.Lancet Public Health. 2018; 3: e323-e332
- Predicting discharge placement and health care needs after lumbar spine laminectomy.J Allied Health. 2014; 43: 88-97
- The use of the Risk Assessment and Prediction Tool in surgical patients in a bundled payment program.Int J Surg. 2017; 38: 119-122
- Comparison of frail patients vs non-frail patients ≥65 years of age undergoing percutaneous coronary intervention.Am J Cardiol. 2012; 109: 1569-1575
- Optimization of surgical outcomes with prehabilitation.Appl Physiol Nutr Metab. 2015; 40: 966-969
- Optimizing functional exercise capacity in the elderly surgical population.Curr Opin Clin Nutr Metab Care. 2005; 8: 23-32
- Personalised prehabilitation in high-risk patients undergoing elective major abdominal surgery: a randomized blinded controlled trial.Ann Surg. 2018; 267: 50-56
- Effect of multimodal prehabilitation vs postoperative rehabilitation on 30-day postoperative complications for frail patients undergoing resection of colorectal cancer: a randomized clinical trial.JAMA Surg. 2020; 155: 233-242
- Prediction of discharge destination following major hepatectomy.HPB. 2019; 21: 1462-1469
- National Surgical Quality Improvement Program (NSQIP) risk factors can be used to validate American Society of Anesthesiologists Physical Status Classification (ASA PS) levels.Ann Surg. 2006; 243 (discussion 641–644): 636-641
Article info
Publication history
Published online: April 25, 2022
Accepted:
March 15,
2022
Footnotes
Priya Pathak and Kota Sahara contributed equally to this work.
Identification
Copyright
© 2022 Elsevier Inc. All rights reserved.