Abstract
Background
Only a few studies have examined the impact of carcinoembryonic antigen variation
in patients before and after curative resection of colorectal liver metastasis . This
study examined the correlation between carcinoembryonic antigen levels and patient
prognosis.
Methods
Patients who underwent curative resection for colorectal liver metastasis between
2000 and 2017 were enrolled. This study examined patients with high preoperative carcinoembryonic
antigen levels that normalized after resection of colorectal liver metastasis and
the correlation between prognosis and time-dependent changes in carcinoembryonic antigen
levels. The similarity in the risk of recurrence in patients with normal preoperative
carcinoembryonic antigen levels was evaluated.
Results
A total of 143 consecutive patients were included in the study cohort and classified
into the normal preoperative (46 patients), normalized postoperative (57 patients),
and elevated preoperative and postoperative (40 patients) carcinoembryonic antigen
groups. All clinicopathologic characteristics were comparable between patients grouped
according to carcinoembryonic antigen levels. The 5-year disease-free survival and
overall survival rates for all patients were 30.4% and 56.0%, respectively. Multivariate
analysis confirmed that elevated preoperative and postoperative carcinoembryonic antigen
levels (hazard ratio = 1.73, 95% confidence interval: 1.04–2.87) were independently
associated with poor disease-free survival; normalization of postoperative carcinoembryonic
antigen (hazard ratio = 0.94, 95% confidence interval: 0.57–1.53) was statistically
indistinguishable from normal preoperative carcinoembryonic antigen levels. The risk
of recurrence was similar to that of patients with normal preoperative carcinoembryonic
antigen levels
Conclusion
Patients with elevated preoperative carcinoembryonic antigen levels that normalized
after resection of colorectal liver metastasis were not at risk of poor disease-free
survival. Elevated carcinoembryonic antigen levels after surgery are independent prognostic
factors for disease-free survival.
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Article info
Publication history
Published online: May 27, 2022
Accepted:
March 25,
2022
Identification
Copyright
© 2022 Elsevier Inc. All rights reserved.
