Big data exposes the tip of the LARS iceberg

      Multidisciplinary treatment algorithms for rectal cancer are often complex and may take many months to complete. Total neoadjuvant treatment for locally advanced rectal cancer, for example, typically includes systemic induction chemotherapy followed by short-course radiotherapy or long-course chemotherapy, and then surgical resection several weeks later. With a subsequent postoperative recovery, the patient may spend the better part of a year in treatment. If a temporary diverting stoma is required, there may be a further delay to restoration of bowel continuity.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Surgery
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Emmertsen K.J.
        • Laurberg S.
        Low anterior resection syndrome score: development and validation of a symptom-based scoring system for bowel dysfunction after low anterior resection for rectal cancer.
        Ann Surg. 2012; 255: 922-928
        • Garfinkle R.
        • Dell’Aniello S.
        • Bhatnagar S.
        • Boutros M.
        Assessment of long-term bowel dysfunction after restorative proctectomy for neoplastic disease: a population-based cohort study.
        Surg Oncol. 2022; 172: 782-788
        • Keane C.
        • Fearnhead N.S.
        • Bordeianou L.
        • et al.
        International consensus definition of low anterior resection syndrome.
        Colorectal Dis. 2020; 22: 331-341
        • Lawrie T.A.
        • Green J.T.
        • Beresford M.
        • et al.
        Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic cancers.
        Cochrane Database Syst Rev. 2018; 1CD012529

      Linked Article