Pancreatic neuroendocrine neoplasms (PNEN) account for <2% of all pancreatic tumors;
however, their incidence is increasing due to increasing use of cross-sectional imaging.
Most PNENs are small, benign, indolent tumors, but some can be aggressive. Surgery
remains the only curative mode of treatment, and despite improvement in surgical techniques
and safety, pancreatic resection continues to carry a significant risk of surgical
morbidity. Numerous staging and prognostication systems
1
have been developed to predict the clinical behavior of PNENs; however, this continues
to be a clinical challenge. Additional study of novel prognostic factors is necessary
to optimize treatment (or surveillance) plans and improve patient outcomes.To read this article in full you will need to make a payment
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References
- Systematic review of current prognostication systems for pancreatic neuroendocrine neoplasms.Surgery. 2019; 165: 672-685
- Discrepancies between two alternative staging systems (European Neuroendocrine Tumor Society 2006 and American Joint Committee on Cancer/Union for International Cancer Control 2010) of neuroendocrine neoplasms of the pancreas: a study of 50 cases.Pathol Res Pract. 2011; 207: 220-224
- Developing a multivariable prognostic model for pancreatic endocrine tumors using the clinical data warehouse resources of a single institution.Appl Clin Inform. 2010; 1: 38-49
- Predicting aggressive behavior in nonfunctioning pancreatic neuroendocrine tumors.Surgery. 2013; 154: 785-793
- Diagnostic concordance of reporting lymphovascular invasion in breast cancer.J Clin Pathol. 2018; 71: 802-805
Article Info
Publication History
Published online: November 14, 2022
Accepted:
October 4,
2022
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2022 Elsevier Inc. All rights reserved.
