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Commentary on “Venous Invasion and Lymphatic Invasion are Correlated With The Postoperative Prognosis Of Pancreatic Neuroendocrine Neoplasm.”

  • Christopher D. Raeburn
    Correspondence
    Corresponding author: Christopher D. Raeburn, MD, Division of GI, Trauma, and Endocrine Surgery, University of Colorado School of Medicine, Department of Surgery, 12631 E. 17th Ave, Mail Stop C313, Aurora, CO 80045.
    Affiliations
    Division of GI, Trauma, and Endocrine Surgery, University of Colorado School of Medicine, Department of Surgery, Aurora, CO
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Published:November 14, 2022DOI:https://doi.org/10.1016/j.surg.2022.10.006
      Pancreatic neuroendocrine neoplasms (PNEN) account for <2% of all pancreatic tumors; however, their incidence is increasing due to increasing use of cross-sectional imaging. Most PNENs are small, benign, indolent tumors, but some can be aggressive. Surgery remains the only curative mode of treatment, and despite improvement in surgical techniques and safety, pancreatic resection continues to carry a significant risk of surgical morbidity. Numerous staging and prognostication systems
      • Teo R.Y.A.
      • Teo T.Z.
      • Tai D.W.M.
      • Tan D.M.
      • Ong S.
      • Goh B.K.P.
      Systematic review of current prognostication systems for pancreatic neuroendocrine neoplasms.
      have been developed to predict the clinical behavior of PNENs; however, this continues to be a clinical challenge. Additional study of novel prognostic factors is necessary to optimize treatment (or surveillance) plans and improve patient outcomes.
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