Euglycemic diabetic ketoacidosis (EDKA), which was first described by Munro et al
1
in 1973, is a clinical syndrome characterized by euglycemia (blood glucose <250 mg/dL)
in the presence of severe metabolic acidosis (arterial pH <7.3; serum bicarbonate
<18 mEq/L) and ketonemia. In EDKA, delayed diagnosis and treatment (due to the absence
of hyperglycemia) might induce serious and severe and life-threatening complications.
In particular, EDKA after pancreaticoduodenectomy (PD) is still poorly understood
and under-recognized, primarily because no large studies have specifically evaluated
EDKA after PD; current literature is limited to case reports.To read this article in full you will need to make a payment
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References
- Euglycaemic diabetic ketoacidosis.Br Med J. 1973; 2: 578-580
- Starvation ketoacidosis: a cause of severe anion gap metabolic acidosis in pregnancy.Case Rep Crit Care. 2014; 2014: 906283
- Euglycemic diabetic ketoacidosis: a review.Curr Diabetes Rev. 2017; 13: 315-321
- Newer perspectives of mechanisms for euglycemic diabetic ketoacidosis.Int J Endocrinol. 2018; 2018: 7074868
Article info
Publication history
Published online: November 26, 2022
Accepted:
October 14,
2022
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2022 Elsevier Inc. All rights reserved.
ScienceDirect
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- Euglycemic diabetic ketoacidosis (EDKA) after pancreaticoduodenectomy: An under-recognized metabolic abnormality with outcome implicationsSurgery
- PreviewEuglycemic diabetic ketoacidosis is a metabolic condition characterized by relative euglycemia, ketonemia, and metabolic acidosis that occurs through mechanisms resembling starvation. Pancreaticoduodenectomy is a complex abdominal operation that subjects patients to a prolonged fasting and an inflammatory state. This study examined the incidence of euglycemic diabetic ketoacidosis and potential opportunities for early diagnosis and management in patients undergoing pancreaticoduodenectomy.
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