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- 1.1. Dogs, receiving intraperitoneal doses of 30 to 100 grams of fresh, ground, adult dog liver, die usually within twenty-four hours, showing all the signs and blood chemical changes of shock.
- 2.2. When the dose is less than 30 grams for an average dog, there is a definite relationship between the interval of survival and the amount of liver introduced. One dog receiving gram per kg. (5 grams total dose) survived indefinitely.
- 3.3. In the dogs which died, peritoneal smears and cultures taken shortly before death consistently revealed growth of the dog liver anaerobe.
- 4.4. We have found the parenchymal elements of the liver to be relatively nontoxic. When these elements were separated from the blood vessel, bile duct, and connective tissue portions of fresh dog liver, 70 grams of the parenchymal tissue suspension caused neither death nor shock. However, 50 grams of the connective tissue suspension caused both shock and death.
- 5.5. Cultures taken of the parenchymal suspensions have consistently showed that this fraction of liver harbors the dog liver anaerobe. Nevertheless, smears and cultures of peritoneal exudate removed from dogs subjected to the intraperitoneal introduction of parenchymal suspensions of liver have shown that these animals rapidly sterilize the peritoneal cavity, even in the presence of large amounts of contaminated liver substance.
- 6.6. The dogs receiving the liver connective tissue suspensions rapidly died of shock and bacterial peritonitis, while the dogs receiving the parenchymal liver suspensions survived and remained well. This interesting observation merits further investigation.
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Received: August 13, 1936
© 1937 Published by Elsevier Inc.