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Abstract
Experimental studies designed to show the behavior of free transplants of fat were
made on 185 white adult rats of average size. In each instance subcutaneous or peritoneal
fat was transferred to a subcutaneous pocket in the thoracic region. The rats were
divided into five groups, depending on the treatment received by the graft immediately
prior to its transplantation. Group A comprised the rats in which autotransplants
of fat of the groin were transferred as a single piece without trauma. Group B included
those in which autotransplants of fat of the groin were cut into multiple pieces with
a sharp razor. Group C included those in which autotransplants of fat of the groin
were severely traumatized by squeezing with a hemostat. Group D comprised those in
which homotransplants of fat of the groin were transferred without trauma. Group E
included those in which autotransplants of fat obtained from the peritoneal cavity
were transferred without trauma.
The rats in the first four groups were killed at intervals of one, two, and three
weeks and one, two, three, four, six, nine, and twelve months after the operation.
In the last group they were killed at one week and one, four, nine, and twelve months
after the operation. At each examination the surviving grafts were studied grossly
and microscopically. All of the sections were stained with sudan III and a few were
stained with hematoxylin and eosin.
The homotransplants survived only for a short time; none was found after the third
month. The crushed grafts and those composed of multiple pieces survived a little
longer. The autografts of subcutaneous and peritoneal fat, which were transferred
without trauma, persisted for a year although they were from one-third to one-half
of their original size (Fig. 8).
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References
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Article info
Publication history
Received:
June 18,
1937
Footnotes
☆Abridgment of thesis submitted to the faculty of the Graduate School of the University of Minnesota in partial fulfillment of the requirements for the degree of Master of Science. The work was done at the Institute of Experimental Medicine.
Identification
Copyright
© 1938 Published by Elsevier Inc.
