Original communication| Volume 4, ISSUE 2, P249-252, August 1938

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The effect on the blood flow of decreasing the lumen of a blood vessel

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      The carotid artery of a dog may be constricted to a considerable degree before the blood flow is reduced significantly. The results may be given in terms of the reduction in external diameter, internal diameter, or area of lumen. The external diameter of a blood vessel (5 mm. in diameter and with a wall 0.325 mm. thick) may be reduced 40 per cent without a significant reduction in blood flow, but, if the external diameter is reduced 60 per cent, the blood flow is reduced 49 per cent. On the other hand, the internal diameter can be reduced 70 per cent before a 50 per cent reduction in blood flow takes place. The data are most striking when stated in terms of the area of the lumen. The area of the lumen may be reduced 50 per cent without any change in blood flow, and it can be reduced as much as 90 per cent before a 50 per cent reduction in blood flow occurs.
      The data were obtained with constricting units of not more than 1 cm. in length.
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