Original communication| Volume 4, ISSUE 5, P680-686, November 1938

The use of vitamin B1 in the preoperative preparation of the hyperthyroid patient

  • William D. Frazier
    From the Surgical Service of the Hospital of the University of Pennsylvania Philadelphia, Pa. USA

    From the Harrison Department of Surgical Research, School of Medicine, University of Pennsylvania Philadelphia, Pa. USA
    Search for articles by this author
  • I.S. Ravdin
    From the Surgical Service of the Hospital of the University of Pennsylvania Philadelphia, Pa. USA

    From the Harrison Department of Surgical Research, School of Medicine, University of Pennsylvania Philadelphia, Pa. USA
    Search for articles by this author
      This paper is only available as a PDF. To read, Please Download here.


      It is our opinion that the severely thyrotoxic patients have been benefited by the administration of vitamin B1. Not only is the nutritional state improved, as evidenced by increased appetite and weight gain, but also patients with severe hyperthyroidism can be adequately prepared for operation in a shorter time. That the vitamin treated cases showed a greater fall in heart rate during the preparatory period suggests that the tachycardia may have been due, in part, to a vitamin B deficiency and, therefore, was improved by the administration of adequate amounts of this vitamin.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Surgery
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Weiss S.
        • Wilkins R.W.
        The Nature of Cardiovascular Disturbances in Vitamin Deficiency States.
        Tr. A. Am. Physicians. 1936; 51: 341
        • Cowgill G.R.
        The Vitamin B Requirement of Man.
        Yale University Press, New Haven1934
        • Hendricks W.A.
        The Relation of Vitamin B Requirement to Metabolism.
        Am. J. Physiol. 1933; 105: 678
        • Brodie J.B.
        • MacLeod F.L.
        Quantitative Experiments on the Occurrence of Vitamin B in Organs.
        J. Nutrition. 1935; 10: 179
        • Harris L.J.
        • Leong P.C.
        Excretion of Vitamin B, in Human Urine and Its Dependence on the Dietary Intake.
        Lancet. 1936; 1: 886
        • Sherman H.C.
        General Review of Our Present Knowledge of Vitamins.
        Bull. N. Y. Acad. Med. 1934; 10: 457
        • Sure B.
        Unusual Response of Nursing Young to Vitamin B (Complex) Administration.
        J. A. M. A. 1927; 89: 675
        • Buchanan J.A.
        The Cause and Treatment of Phases of Vitamin B Deficiency in Man.
        M. J. & Rec. 1932; 155: 234
        • Elsom K.O'S.
        Experimental Study of Clinical Vitamin B Deficiency.
        J. Clin. Investigation. 1935; 14: 40
        • Cowgill G.R.
        • Gilman A.Z.
        The Effect of Lack of the Vitamin B Complex on the Secretion of Gastric Juice in Dogs With Gastric Pouches.
        Arch. Int. Med. 1934; 53: 58
        • Fitts J.B.
        Motor and Secretory Dysfunction of the Gastro-Intestinal Tract and the Vitamin B1 Factor.
        South. M. J. 1935; 28: 920
        • Hinwich H.E.
        • Goldfarb Walter
        • Cowgill G.R.
        The Vitamin B Complex in Relation to Food Intakes During Hyperthyroidism.
        in: Proc. Soc. Exper. Biol. & Med. 28. 1931: 646
        • Brown R.B.
        • Mecray P.M.
        Serum Proteins Before and After Operations for Hyperthyroidism.
        Endocrinology. 1938; 22: 302
        • Sankaran G.
        • Krishnan B.G.
        Observations on the Heart Rate in Vitamin B1 and C Deficiency.
        Indian J. M. Res. 1936; 23: 747
        • Jones W.A.
        • Sure B.
        The Role of Vitamin B1 in Cardiovascular Diseases.
        J. Lab. & Clin. Med. 1937; 22: 991
        • Zoll P.M.
        • Weiss S.
        Electrocardiographic Changes in Rats Deficient in Vitamin B1.
        in: Proc. Soc. Exper. Biol. & Med. 35. 1936: 259
        • McCarrison R.
        Contributions to the Study of Experimental Beriberi.
        Indian J. M. Res. 1914; 2: 369
        • Stepp W.
        • György P.
        Avitaminosen und Verwandte Krankheitszustande.
        in: Julius Springer, Berlin1927: 158
        • Spence A.W.
        The Effect of Vitamin Deficiency on the Structure of Thyroid and Thymus Glands.
        Brit. J. Exper. Path. 1932; 13: 157
        • Fischer E.
        Kropferzeugung und Kropfverhutung im Rottenversuch.
        Schweiz. med. Wchnschr. 1933; 30: 749
        • Sandberg M.
        • Holly O.M.
        Influence of Vitamin B and Iodine on Calcium and Phosphorus Metabolism of Rabbits With Hyperplastic Thyroids.
        J. Biol. Chem. 1933; 99: 547
        • Carpenter M.D.
        • Sharpless G.R.
        A Study of the Effect of Vitamin B and Iodine on the Weight, Iodine Content and Structure of the Thyroid Gland of the Rat.
        J. Nutrition. 1937; 13: 234
        • Means J.H.
        • Hertz S.
        • Lerman J.
        Nutritional Factors in Graves' Disease.
        Ann. Int. Med. 1937; 11: 429
        • Sure B.
        • Smith M.
        Hyperthyroidism and Nutrition.
        J. Nutrition. 1934; 7: 547
        • Sure B.
        • Buchanan K.S.
        Antithyrogenic Action of Crystalline Vitamin B1.
        J. Nutrition. 1937; 13: 513
        • Plimmer D.H.A.
        • Rosedale J.L.
        Vitamin B Requirement Related to Food Intake.
        Biochem. J. 1923; 17: 772
        • Peters R.A.
        The Biochemical Lesion in Vitamin B1 Deficiency.
        Lancet. 1936; 1: 1161
        • Drill A.V.
        The Effect of Yeast on Liver Glycogen of Rats During Hyperthyroidism.
        J. Nutrition. 1937; 14: 355
        • Abderhalden E.
        • Wertheimer E.
        Weitere Beobachtungen uber Beziehungen des Vitamin B-komplexes (ins besondere des Vitamin B1) zum Kohlenhydrathaushalt.
        Arch. f. d. ges. Physiol. 1934; 53: 235
        • Tislowitz R.
        Vitamin B1 und Kohlenhydratstoffwechsel.
        Klin. Wchnschr. 1937; 16: 226
        • Funk C.
        • Schönborn E.
        The Influence of a Vitamin-Free Diet on Carbohydrate Metabolism.
        J. Physiol. 1914; 48: 328
        • Sure B.
        • Smith M.E.
        The Effect of a Deficiency of the Vitamin B Complex on the Lipid Metabolism and Glycogen Content of the Liver of the Albino Rat.
        Arch. Int. Med. 1932; 49: 397
        • Lajos S.
        Ueber die Wirkung des B1-Vitamins auf den Kohlenhydratstoffwechsel.
        Biochem. Ztschr. 1936; 284: 278
        • Frazier C.H.
        • Brown R.B.
        The Thyroid and the Liver.
        Tr. Am. A. Study Goiter. 1935;
        • Lahey F.H.
        The Management of Severe Hyperthyroidism.
        Surg., Gynec. & Obst. 1937; 64: 304
        • Meyler L.
        Investigations on the Treatment of Thyrotoxicosis.
        Acta med. Scandinav. 1937; 93: 48
        • Abelin I.
        Ernahrung und Schilddrusenwirkung.
        Biochem. Ztschr. 1930; 228: 165